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3 The Turkish scientist was able to genetically engineer the immune cells obtained from the patient's blood sample and turn them into more powerful fighters against the cancer cells. The work of the team was published in the European Journal of Immunology.
Bioengineers Tolga Sütlü (38), Adil Doğanay Duru (38); Dr. Batu Erman (50) reprogrammed the cells of the immune system and circled them with "war tools". In other words, it strengthened the mechanisms by which the immune system could better fight against cancer. One of the project leaders said that this procedure could be called "cellular immunotherapy". Dr. Tolga Sutlu, the blood cells of the patient's own immune system, cancer cells must be recognized and distinguished from healthy cells genetically reprogrammed, he said.
"TARGET MOLECULES IN"
Two main groups of cells can be used in our immune system. CAR-T cells, which are currently highly successful clinically, can target cancer cell molecules by differentiating them from healthy cells and killing them. "These are the cells that can target the molecules on their surface, not the CAR-T cells." he said.
PROCESS FIND A FEW WEEKEND
The modification and preparation of the cells takes about a week. To be returned to the patient at a certain dose, the number must also be replicated. This can take 1 to 2 weeks depending on the growth rate of the cells. Dr. "Such processes result in the production of billions of genetically modified cells in 2-3 weeks, starting with a few million cells purified from the blood sample taken from the patient," he said. he declares.
Seek help for further work
In this first published step of the study, they developed this technology using human cell lines and demonstrated in experimental animal models that it was a problem. effective treatment. The team is now seeking support to work on patient samples. Dr. Milky says:
"We applied TÜBİTAK together with Uludağ University, if it was accepted, we would be able to do the second stage of the studies, in this part we plan to continue for three years, and then we can start our studies. third stage, clinical trials, that we can give back to patients for treatment. "
APPLICATION FOR PATENT FOR WORK
The team started with melanoma to show that the method worked. Because there is a vast literature on the applications of immunotherapy in melanoma. But theoretically, this new method can be applied to all types of cancer, even to viral infections. The project was carried out in cooperation with Sabancı and Nova Southeastern Universities and a patent application was filed in partnership with two universities.
"CELEBRATE THE SPECIFIC RESPONSE OF CELLS"
Genetically modified cells are used in the laboratory to perform genetic modifications. Because viruses put their genes out of the cell. Dr. Tolga Sutlu and colleagues at the lab aim to remove genes from the virus and put them into treatment. Thus, the virus in the cell, not the genes that pass, the gene is transmitted to the desired genes.
Dr. Sütlü explains this process in the following way: "Thanks to the genes we transmit, we help NK cells to distinguish cancer cells from cancer cells by recognizing cancer-specific molecules." The cells we have prepared have the ability to detect and kill only those with cancer, without damaging healthy tissue.NK cells give a specific response. "We created specific NK cells to respond. So we created a new cell type.
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