US Coronavirus: With More Covid-19 Recalls On The Horizon, Expert Says Mixing And Matching Doses May Be An Effective Approach



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“I hope that when the FDA and CDC review the data on Moderna and Johnson & Johnson, they will allow for a mixed approach,” CNN medical analyst Dr. Leana Wen said on Friday.

U.S. Food and Drug Administration vaccine advisors will meet on October 14 and 15 to discuss booster dose requests from Moderna and J&J’s vaccine arm, Janssen. And on October 20 and 21, vaccine experts from the U.S. Centers for Disease Control and Prevention are expected to discuss the same course of action.

Wen, also a former Baltimore City Health Commissioner, said allowing the mix-and-match option is more convenient for those who initially received the Pfizer or Moderna vaccines in the event that one of the vaccines recall is not available where they go to shoot them.

“The mRNA vaccines really should be interchangeable,” she said.

The vaccines from Pfizer and Moderna both use genetic material called messenger RNA (mRNA) to deliver immunity, but they use different doses and slightly different formulations. J & J’s Janssen vaccine uses an inactivated cold virus called adenovirus – a viral vector – to carry genetic instructions around the body.

But Wen warned that people who have received the J&J vaccine may need to consider the risks associated with taking her booster dose.

“We know there is an association between the Johnson & Johnson vaccine and a very rare – but extremely serious – blood clotting disorder in women under 50,” Wen told CNN. She added that even though she was fully vaccinated with the Johnson & Johnson vaccine, she would prefer to receive a different vaccine booster.

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Dr Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases, said late last month that “mix and match” studies are underway.

“The mix-and-match study in which you see Moderna as the boost against the other three, that data is now available,” Fauci said during a White House briefing on Covid-19.

The data has not yet been published or submitted to the FDA.

Already, CDC data shows more than 6 millions of fully immunized Americans received a booster dose. On average, 390,444 people receive a booster each day, while only 288,105 people start their immunization series each day and 276,539 people are fully immunized each day.

Additionally, some immunocompromised people may be given a third dose, although this is not technically considered a booster, as it is likely that they did not fully respond to the first two doses.

Global infections are down, but experts warn of complacency

Yet experts warn that the primary public health focus must remain on getting initial vaccines into the arms of the millions of Americans who are not vaccinated at all.

“As a country, we are definitely going in the right direction – finally,” said Wen. “The problem, however, is that people really need to watch where they are. Wrong direction.”

Covid-19 infections are down almost 35% from last month, and the number of people fighting the virus in hospitals has fallen by more than 31% from the previous month, according to University data Johns Hopkins and the US Department of Health and Human Services. , respectively.

But experts, including Wen and US Surgeon General Dr Vivek Murthy, warn against complacency as there are still areas showing increasing trends in deaths and hospitalizations.

Fewer hospitalizations linked to Covid-19, more vaccinations show that the United States may be on the verge of the pandemic, but experts warn:

“Fortunately, we’re seeing fewer cases and fewer hospitalizations, but that’s no reason for us to take our foot off the accelerator or slack off our guards,” Murthy said earlier this week.

In Alabama, infections have declined in recent weeks, but people are still dying from the disease at high rates, a senior state health official said on Friday.

“Very fortunately, we have had a drop in our number of hospitalizations.… We have dropped to just over 1,000 inpatients in the state,” said state health official Dr Scott Harris. He acknowledged that the number was still high, “but it’s about two-thirds less than what we were seeing about a month ago.”

He added: “We haven’t really seen a change in the number of deaths, unfortunately.”

And Pennsylvania reported the highest number of hospitalizations for Covid-19 since February, a spokesperson for the state’s health department said. Of the 3,001 people hospitalized with the virus, 680 were in intensive care units on Thursday, officials said.

A vial with the Moderna Covid-19 vaccine sits on a table at a homeless clinic in San Julian Park in Los Angeles, California.

Covid-19’s racial and ethnic disparity gap narrows but remains wide

Meanwhile, black and brown communities have borne the brunt of the Covid-19 pandemic. Racial and ethnic minority groups had higher hospitalization rates for Covid-19 and sought more emergency room care for Covid-19 than whites, according to CDC studies published in April.

A new analysis released Friday by the Kaiser Family Foundation (KFF) shows that the difference in Covid-19 cases and deaths between blacks, Hispanics and whites is narrowing.

Covid-19 has claimed parents or grandparents of 140,000 American children, and minorities have been hit hardest

KFF researchers found that while disparities are still present between different racial groups, the gap is improving for blacks and Hispanics, based on an analysis of data on the cases and deaths of the CDC last month. But Covid-19 infections remain high among Native Americans and Alaska Natives.

The most recent data included in the report, from September 25, shows a case rate of 96.1 Covid-19 infections per 100,000 whites. Among Hispanics, that number was 90.8; among blacks it was 92.7.

The Native American and Native communities of Alaska recorded the highest case rate per 100,000 people, at 181. Asians had the lowest case rate: 42.9 per 100,000 people.

Meanwhile, a CDC report released Thursday showed that children of racial and ethnic minorities were much more likely to lose a parent or grandparent who cares for them.

Data from the National Center for Health Statistics through June showed that racial and ethnic minority children made up 65% of those who lost a primary caregiver, while white children made up 35%. This is even if minorities make up only 39% of the American population.

CNN’s Lauren Mascarenhas, Virginia Langmaid, Maggie Fox, Melissa Alonso and Laura Studley contributed to this report.

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