Live probiotics can alter intestinal flora and immune response

New research published in the International Journal of Pharmacy demonstrates that the "good" bacteria of the living probiotic Symprove^TM can successfully reach and colonize the intestine, and then change the existing intestinal flora. They are also able to modify the immune response.

The researchers found that all the bacteria in Symprove had survived the stomach acid to reach and colonize the intestine. The activity of the bacteria in this study was observed with the aid of a new simulator of the human intestinal microbial ecosystem (SHIME) and used donor bacteria of human beings in good health. This allows researchers to closely monitor bacteria through an in vitro simulation of the intestine, without resorting to invasive procedures and measures.

The bacteria in Symprove have been tested to determine if their colonization would help feed the gut microbiome through lactate production. The microbiome has been identified as a modifier of the disease and an essential part of immunity.

Simon Gaisford, professor of pharmacy at University College London, says, "We have been able to demonstrate that the administration of viable and active bacteria in the gut has an impact on the healthy bacteria of our body The diversity of donor microbiota clearly changed for the better and, importantly, the effect was maintained week after week.We found that the addition of Symprove reduced the markers inflammatory and increased levels of butyrate.If we could make a healthy microbiome healthier, the potential for improvement of dysbiosis is incredibly exciting. "

The addition of probiotics contained in Symprove to microbiota of healthy human donors has altered the proportion of bacterial groups in the intestinal flora, which has resulted in a significant increase in butyrate – a short-chain essential fatty acid (SCFA) for health and well-being.

The addition of Symprove also increased the anti-inflammatory cytokines IL-6 and IL-10, while reducing the inflammatory chemokines IL-8, MCP-1 and CXCL10, associated with inflammatory conditions and viral infections. The data showed that the microbiome's diet induced changes in intestinal flora as well as a positive anti-inflammatory and immunomodulatory effect.

An increase in the abundance of beneficial bacteria such as firmicutes and actinobacteria has also been observed after the addition of Symprove bacteria in the simulation containers. A lack of these bacteria in the intestine is associated with several health problems, including irritable bowel syndrome.

"As more research looks at the microbiome and its relationship to health in general, the positive impact of water-based specialty probiotics will be increasingly recognized." The data suggests that the main benefit of Probiotics is their ability to support the existing flora in the microbiome to help rebalance it, "said Barry Smith, Symprove Limited founder and chairman of the board of directors. "Our research over the last 20 years has led to a better understanding of the microbiome and its critical role in our overall health.This new research demonstrates the impact that live and active probiotics can have on the body beyond the average. It's incredibly exciting, renowned academics recognize the impact of microbiome feeding.We all have a microbiome and, in many cases, we simply need to help existing bacteria. "