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An international study by scientists from the University of Manchester has revealed the identity of genes that predispose people to chronic kidney disease.
This discovery is a major advance in understanding the significantly underdiagnosed disorder that, if not detected, can lead to kidney failure requiring dialysis or kidney transplantation.
The discovery of 35 kidney genes is an important advance in the future development of new diagnostic tests and treatments for the disease, which affects about one in ten adults.
The team, based in Poland, Australia and the United Kingdom, publishes the study funded by Kidney Research UK in Nature Communications aujourd & # 39; hui.
Professor Maciej Tomaszewski of the University of Manchester, principal investigator, said: "Chronic kidney disease is known for its strong genetic component.
"Our limited knowledge of its exact genetic mechanisms partly explains why progress in developing new diagnostic tests and treatments for chronic kidney failure have been so slow.
"The results were made possible through the use of advanced technology known as" next-generation DNA sequencing "applied to one of the largest collections of human kidneys never realized.
"We hope that some of the kidney genes we have discovered will become attractive targets for the development of future diagnoses and treatments for patients with chronic renal failure."
Professor Adrian Woolf, co-author of the Manchester Children's Hospital and the Manchester Universality, said: "One of the genes, mucin-1, is particularly interesting.
"It produces a sticky protein called mucin that covers the urinary tubes inside the kidney.Monations of this gene have already been discovered in rare families with hereditary renal failure"
Professor Fadi Charchar, of the Federation University Australia, said: "We hope that early prediction through genetic testing, even before the symptoms develop, will be the first line of defense against one of the deadliest of the world."
"Early detection followed by treatment using protective drugs of the kidneys or the avoidance of drugs that can damage the kidneys is the key to kidney health later in life."
Elaine Davies, director of research operations at Kidney Research UK, said: "According to their treating physician, almost 2 million people in the UK have been diagnosed with moderate to severe renal impairment, but it is estimated that One million people remain undiagnosed.notic killer because it is common that it shows little or no symptoms until the consequences of the disease have not appeared.
"The results of this research are extremely important as they bring us closer to the ability to understand, diagnose earlier and prevent kidney disease."
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