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The findings, which were presented at the annual conference of the Society for Endocrinology in Glasgow, indicate that improving skin health could be of major importance for glycemic control and reduction. the risk of diabetes.
About 2 to 3% of the world's population suffers from psoriasis, a chronic inflammatory disease in which the immune system attacks skin cells, leading to excessive growth of younger skin cells, resulting in red itchiness. Unfortunately, there is currently no cure for psoriasis, as patients need to use treatments to alleviate symptoms throughout their lives.
To add to this burden, previous studies have shown that psoriasis increases the risk of developing type 2 diabetes. However, the specific biological mechanisms that link the two disorders are unknown and, if they are defined, they could lead to new therapies to treat patients with skin problems and reduce the risk of type 2 diabetes.
In this study, Elizabeth Evans and colleagues from King's College London used animal and human skin models to look for changes caused by psoriasis that could influence the development of diabetes.
Mice with psoriasis showed changes indicating insulin resistance, an essential feature of diabetes development when insulin does not stimulate glucose uptake into cells. The changes included a decrease in the ability of glucose uptake in subcutaneous adipose tissue and an increase in insulin production by insulin-producing cells, indicating that body tries to compensate for the lack of glucose absorption.
Similar alterations have been observed in fat cells and islets located outside the body during exposure to the culture fluid used to support inflamed skin samples, suggesting that inflamed skin releases chemical signals that cause the changes.
Elizabeth Evans commented, "The laboratory model we used in this study is very similar to most of the major features of psoriasis and we have observed some changes caused by the disease that reflect what we see in a patient. pre-diabetic. "
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