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Cancer cells typically have a "re-homing" behavior in which cells that have metastasized return to the original tumor. Scientists took advantage of this feature to use cells created by CRISPR to turn against their own species. ( Pixabay )
Can cancer cells be designed to turn against their own species? Boston scientists took advantage of the typical behavior of cancer cells and used CRISPR technology in the hope of destroying the main tumor with its own cells
Cancer Cell Assassins
Hospital Researchers Brigham and Women recently took on the fight against cancer, and they were able to do that by taking advantage of the typical behavior of cancer cells. Normally, cancer cells have a "self-homing" behavior in which cells that have metastasized or spread to other parts of the body can follow the main tumor and other cells of their own type.
the researchers introduced S-TRAIL, a protein that kills various types of cancer cells and is not toxic to healthy cells, in cancer cells of mice and then transfers them into the body. The idea is that these CRISPR-modified cells can then kill the other cancer cells that they encounter but also have a so-called "suicide switch" that causes them to kill themselves before they can begin to spread or develop tumors. [19659005L'équipeautilisél'approcheCRISPRpourintroduireS-TRAILdanslescellulescancéreusesenutilisantdeuxméthodesetadécouvertquechezlessourisatteintesd'uncancerprimitifducerveaud'uncancerrécurrentducerveauetd'uncancerduseinmétastaséaucerveaulescellulesmodifiéesintroduitdanslecorpsestallédirectementauxtumeursetaégalementtuélescellulescancéreusesLesdeuxtypesdecellulesmodifiéesontétécapablesderéduiredemanièresignificativelatailledelatumeurchezlessourisquiontreçuletraitementparrapportauxsourisquinel'ontpasEnoutreleschercheursontégalementsignaléquelessourisquiontreçuletraitementvivaientaussipluslongtemps
Closer To A Cure?
Do the results of the study show that science is one step closer to healing? Perhaps, but there are several obstacles that therapy could still have to face. For example, this is not the first time that the re-homing behavior of cancer cells has been used to kill cells. Previous studies have also used cancer-killing viruses or cells with a suicide change, but the success of the treatment has yet to be found.
In addition, there is still a lot of testing to do before the method becomes an approved cancer treatment. On the one hand, there is still no guarantee that treatment will be as effective in humans as in mice.
That said, the team is not deterred by roadblocks. In fact, the study leader, Khalid Shah, MS, PHD, and his team plan to create a start-up that will focus on transferring cancer cells into the tumor's own killers. In addition, he also states that even after submitting their results for publication, the team has already gathered solid evidence of how the method works in the attack and destruction of cancer cells
" Our study demonstrates the therapeutic potential of tumor cells and their self-homing properties to develop receptor-targeted therapeutics for various cancers, "said Shah.
The study is published in Science Translational Medicine .
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