FDA Accepts Tafenoquine (Krintafel) to Prevent Malaria Relapse

The United States Food and Drug Administration (FDA) has approved tafenoquine ( Krintafel ) to prevent the relapse of Malaria Plasmodium vivax in persons aged 16 and over. more who receive appropriate antimalarial treatment for acute infection P vivax GlaxoSmithKline (GSK) and Medicines for Malaria Venture (MMV) announced.

Tafenoquine is the first new treatment for malaria P vivax in more than 60 years. years and is the first single-dose drug for this type of recurrent malaria, according to GSK. "With our partner, Medicines for Malaria Venture, we believe that Krintafel will be an important medicine for malaria patients and will contribute to ongoing efforts to eradicate this disease," he added. Barron, MD, GSK's Scientific Director and President of Research and Development, said in a statement: "The US FDA's approval of Krintafel is a milestone and a significant contribution to global efforts to eradicate malaria ", added David Reddy. PhD, general manager of MMV. "The world has waited decades for a new drug against the relapse of malaria P vivax Today, we can say that the wait is over.Also, as the first single dose for this indication, Krintafel will help improve the patient We are now working to ensure that the drug reaches the most vulnerable patients who need it most. "

Tafenoquine is a derivative of 8-aminoquinoline active against all Life Cycle Stages of [P] It was first synthesized by scientists from the Walter Reed Army Research Institute, Silver Spring, Maryland, in 1978. GSK began to Developing tafenoquine as a potential antimalarial over 20 years ago In 2008, the company entered into a collaboration with MMV, a nonprofit pharmaceutical research partnership, to develop tafenoquine.

approving the drug, the FDA reviewed data from 33 studies involving more than 4000 participants who received the single 300 mg dose. and other doses of tafenoquine.

It is estimated that P. vivax malaria causes approximately 8.5 million clinical infections each year. It has a significant impact on public health and the economy, mainly in Southeast Asia, Southeast Asia, Latin America and the Horn of Africa.

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