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An experimental cancer vaccine has been found to increase the effectiveness of an existing treatment up to a 100% success rate.
The vaccine, developed by a team at UT Southwestern Medical Center, used a molecule called Diprovocim. It has boosted the effectiveness of cancer-fighting cells in combination with an existing cancer treatment, reports Drug Target Review.
The study, co-led by Professor Dale Boger, Scripps researcher and Nobel Prize winner Bruce Beutler of Southwestern, was published in the Proceedings of the United States National Academy of Sciences.
The research team tested Diprovocim with anti-PD-L1 and alum anti-cancer treatment in mice with melanoma, a type of aggressive cancer that develops from pigment cells called melanocytes. Melanoma usually starts on the skin but can also develop in the mouth, eyes or intestines. In case of early treatment, melanoma can be cured, but it can be fatal if it spreads in the body.
Observations showed a 100% survival rate in mice given PD-L1 with Diprovocim. A 25% survival rate was observed with PD-L1 plus alum and no survival for those receiving only PD-L1 treatment.
What the vaccine did was stimulate the immune system to create and direct cancer cells, or tumor-infiltrating leukocytes, to attack the tumors. Since immunotherapy procedures such as PD-L1 already stimulate the body's natural defenses, the added Diprovocim essentially puts the system in overdrive.
The molecule of Diprovocim was also easy to synthesize, according to scientists, which made its medical application more promising.
In addition to the 100% success rate, the researchers found that the surviving mice developed resistance when they attempted to restore the tumor. "It would not take. The animal is already vaccinated against him, "said Boger.
To move forward, the team plans to do more testing and see how Diprovocim works with other cancer treatments, which could target different forms of cancer. Alfred Bayle / ra
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