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By Susan Scutti, CNN
New research suggests that women who take a regular, low-dose daily aspirin regularly may reduce their risk of ovarian cancer.
The study highlights two important caveats. The daily use of aspirin at standard dose (325 mg) does not reduce the risk of ovarian cancer, and a significant use of non-steroidal anti-inflammatory drugs (NSAIDs) , such as ibuprofen and naproxen, could increase the risk, suggests the study released Thursday. in the medical journal JAMA Oncology.
Another potential limitation: the result was found only in women who had been using low dose aspirin for less than a year.
Aspirin is thought to reduce the risk of ovarian cancer – the fifth leading cause of cancer death among American women – by reducing inflammation, according to the authors.
The new analysis included data on 205,498 women who were part of the Nurses 'Health Study II and the Second Nurses' Health Study, who use questionnaires to track the illness and behavior of women in nursing. health.
Of these women, 1,054 developed ovarian cancer. The research team examined how these women used aspirin, nonacetaminic NSAIDs and acetaminophen and compared their behavior to that of other participants.
The analysis showed that women who had been using low dose aspirin for less than a year had 23% less risk of ovarian cancer than women who did not. did not use aspirin at all. However, women who used low-dose aspirin for five years or more and those who used aspirin at standard dose (325 mg) did not show increased chances of develop ovarian cancer, the study said.
In contrast, the use of NSAIDs without aspirin for less than a year was associated with a 19% increase in the risk of ovarian cancer, according to researchers at Harvard TH School Chan public health found.
NSAIDs taken in amounts of at least 10 tablets a week for several years increased the risk of ovarian cancer by 34%. However, when NSAIDs were used less than two days a week for five years or more, they were not associated with an increased risk of ovarian cancer.
The researchers concluded that older women taking low-dose aspirin to reduce their risk of heart disease are unlikely to increase their risk of ovarian cancer.
Other scientists believe that additional research is needed to verify the results.
Stephen Evans, professor of pharmacoepidemiology at the London School of Hygiene & Tropical Medicine, told Science Media Center the new analysis is "good, but the data limitations mean that the results should be treated with caution".
"The results are slightly confusing with regard to aspirin, with low doses showing reduced risk and higher doses showing increased risk," said Evans, who did not participate in the research . "This could indicate that unmeasured factors explain the results."
"Other pain medications (NSAIDs) and aspirin at higher doses are not reassuring for long-term use," he said. "However, the risk to a particular person, even if these conclusions are correct, is not high and might not be."
Eric J. Jacobs, cancer epidemiologist and strategic director of pharmacoepidemiology at the American Cancer Society, said: "At best, the global evidence suggests that aspirin only slightly decreases the cancer risk of cancer." # 39; ovary.
"There is still too little evidence to conclude that the use of aspirin helps to reduce the risk of liver or ovarian cancer, and people should not take any medicine. Aspirin in the hope of preventing these cancers, "added Jacobs, who did not participate in the research.
The authors of the study also said that further research was needed to understand how "significant use of aspirin, non-aspirin NSAIDs and acetaminophen could contribute to the development of of ovarian cancer ".
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