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Today, much of the biology underlying cells' compositions of lipids is a black box to scientists. Even though they are a major group of biomolecules, they are difficult to study because of their metabolism.
Now, researchers from the Department of Energy's Joint BioEnergy Institute (JBEI), Berkeley Lab, and The Novo Nordisk Foundation Center for Biosustainability at Technical University of Denmark (DTU Biosustain) have found a way to engineer the fatty membranes of cells. The researchers boosted the cells' ability to produce high volumes of fluid fats, so-called unsaturated lipids. This increased membrane respiration as well as the cell's growth rate.
It may be an advantage when engineering the cellular workhorses E. coli or baker's yeast to produce biofuels, biochemicals or biopharmaceuticals. Therefore, this method could become very important in working with cell factories.
The research has been published Science.
The researchers showed how to manipulate the lipid composition of E. coli and baker's yeast. The next step is to show that the method works for mammalian cells as well.
"Multiple diseases, such as type 2 diabetes, lead to more rigid membranes, and also feature impaired mitochondria function," says first-author, Postdoc Itay Budin from JBEI.
Mitochondria are the cell's power plants. Cells with impaired mitochondrial function work slowly compared to normal cells. Making the cells' membrane more fluid could normalize mitochondrial function.
"We are excited about this work – it shows that synthetic biology and metabolic engineering can be applied to basic insights in fundamental biological processes. the mechanisms behind, "says co-author, Professor at JBEI and Scientific Director at DTU Biosustain Jay Keasling.
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Materials provided by Technical University of Denmark. Note: Content can be edited for style and length.
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