[ad_1]
SAN DIEGO – Patients with baseline chronic kidney disease who used marijuana experienced more rapid eGFR decline, according to data presented at ASN Kidney Week 2018.
"It is important to study marijuana in light of the fact of global legalization and increasing use," Joshua L. Rein, DO, from Icahn School of Medicine at Mount Sinai, told Healio Nephrology. "It is important to know its effects on kidney disease."
ASSESS-AKI is a combination of the two types of marriages. A total of 1,599 hospitalized adults who were present in the United States between 2009 and 2015 were included in the analysis. Of these patients, 113 (7%) were marijuana users. Marijuana users were defined as those who reported using marijuana since their last study visit. Participants were followed for a median of 4.1 years.
Marijuana users were more likely to be younger (mean age, 54 vs. 65 years), white (78%), men (78%) and heavy tobacco users, who were defined as smoking 20 or more cigarettes per day (26% vs 8%).
Data indicated marijuana users had a higher baseline eGFR than non-users (87 ± 30 mL / min / 1.73 m² vs. 69 ± 26 mL / min / 1.73 m²); however, UACR baseline was similar among the two groups (120 ± 80 in users vs. 99 ± 72 in non-users).
Marijuana use was not linked to CKD incident (adjusted HR = 0.93, 95% CI, 0.5-1.8) or differences in eGFR slope over time (mean difference, -0.12 mL / min / 1.73 m² per year among participants with a baseline eGFR of 60 mL / min / 1.73 m² or more). Conversely, eGFR was less than 60 mL / min / 1.73 m² compared with non-users (-3.2 vs. -1.4 mL / min / 1.73 m² per year). Marijuana users with an eGFR baseline of less than 60 mL / min / 1.73 m² also had a higher risk for CKD progression (aHR = 2.7; 95% CI, 0.83-8.5).
Among participants with vs. without CKD, marijuana was not correlated with the rate of change in UACR.
"In this study, we saw that patients with marijuana had accelerated decline in their renal function compared to people who did not use marijuana," Rein said. "Renal function in marijuana users with kidney disease should be closely monitored. We do not know the reason for the decline in kidney function. I hypothesize it's because of smoke inhalation. Medical marijuana in the form of vaporization or edibles may not share these same harms. "
"Patients with significant illness, such as nausea, anorexia and chronic pain, which are all validated for medical marijuana use," he continued. "If patients with kidney disease are prescribed marijuana for their symptoms, we need to be mindful of the effects on the kidney." by Alaina Tedesco
Reference:
Rein JL, et al. Abstract FR-PO233. Presented at: ASN Kidney Week; Oct. 23-28, 2018; San Diego.
Disclosure: Healio Nephrology was not available at the time of publication.
[ad_2]
Source link
