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A new study has revealed that microbiota gut, which is the complex community of microorganisms that live in the digestive tract of humans and other animals, has the ability to affect how responds to insulin, and can contribute to diabetes.
The study was published in the Journal of Cell. Scientists at Sahlgrenska Academy, University of Gothenburg, Sweden, showed that the gut microbiota of people with treatment-naive type 2 diabetes can be linked to a different metabolism of the amino acid histidine, which is derived from the diet.
During recent years, the gut microbiota has been associated with several conditions. However, only a few studies have been investigated in the microbiota can directly affect disease.
This, in turn, leads to the formation of imidazole propionate, a substance that causes the cells to respond to insulin.
Reducing the amount of bacterial-produced imidazole propionate could, therefore, be a new way of treating patients with type 2 diabetes.
"This substance does not cause any type of diabetes, but it is likely that there are subpopulations of patients who might benefit from their diet or altering their gut microbiota to reduce the levels of imidazole propionate," said Fredrik Backhed, Professor of Molecular Medicine with a research focus on the role of microbiota gut in metabolism.
The latest study included the analysis of various substances in the blood vessel that goes from the intestine to the liver. The researchers then identified an elevated concentration of the substance imidazole propionate in patients with type 2 diabetes.
Using fecal samples, it was also possible to show that the microbiota of people with diabetes mellitus was imidazole propionate when histidine was added. This mechanism was not found in the diabetes-free control subjects.
The study of five patients with type 2 diabetes and 10 diabetes-free control subjects. The findings were then confirmed in a larger study involving 649 people.
The Gothenburg scientists then proceeded to investigate the effect of imidazole propionate on sugar metabolism and found that the molecule affected a signaling pathway previously linked to metabolic-related diseases by directly activating a specific protein, p38gamma.
These findings are answers to questions about the nature of the underlying mechanisms. These methods are associated with, for example, obesity, diabetes, and cardiovascular disease.
"Our findings show clearly how important the interaction between gut microbiota and diet is to understand our metabolism in health and disease." The result also shows that gut bacteria from different individuals can lead to the production of completely different substances. the body, "said Backhed.
(This story has been edited by Business Standard staff and is self-generated from a syndicated feed.)
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