A major opioid manufacturer must pay for the development of an antidote against overdoses

Geoff Mulvihill, Associated Press

updated

10:33 am PDT, Wednesday 5 September 2018

A company whose prescription opioid marketing practices are accused of triggering the drug and overdose crisis said it was helping to fund an antidote for overdoses at a lower cost.

Purdue Pharma, the maker of OxyContin, announced Wednesday it is providing a $ 3.4 million grant to Harm Reduction Therapeutics, a non-profit organization based in Pittsburgh, to help develop a nasal-based nasal spray. naloxone at low cost.

The announcement comes as local authorities accuse Purdue, based in Stamford, Connecticut, and other pharmaceutical companies of using deceptive marketing practices to encourage mass prescription of powerful and addictive painkillers. Last week, the number of lawsuits against the industry, overseen by a federal judge, exceeded the number of 1,000.

Judge Dan Polster, based in Cleveland, is pushing the industry to agree with plaintiffs – mostly local governments and Native American tribes – and state governments, most of whom have filed lawsuits courts or conduct a joint investigation. Hundreds of other local governments also sue in state courts across the country.

The parties have had regular settlement discussions, but it is unclear when an agreement could be reached in the case, which is complicated by the number of parties and questions about how to attribute the mistakes.

The US Centers for Disease Control and Prevention estimated that overdoses of drugs killed a record 72,000 Americans last year, about 10% more than in 2016. The majority of deaths were in opioids. But a growing number of them come from illicit synthetic drugs, including fentanyl, rather than prescription opioids such as OxyContin or Vicodin.

Governments are calling for changes in the marketing of opioids and help to pay for the treatment and costs of ambulances, child protection systems, prisons and other expenses associated with the opioid crisis.

Polster is expected to rule in the coming weeks on motions from drug manufacturers, distributors and pharmacies to reject claims. Trials in some cases – used to test problems common to many of them – are expected to begin in September 2019.

Purdue agreed to pay $ 634 million in fines in 2007 to settle charges that the company was minimizing the risk of addiction and abuse of its painkiller OxyContin since the 1990s.

He faces similar charges again.

Earlier this year, the private company stopped marketing OxyContin to doctors.

The naloxone grant is one way the company can show that it is trying to help stem the damage done by opioids. "This grant is an example of the significant steps Purdue has taken to help combat opioid abuse in our communities," said Craig Landau, President and CEO of Purdue, in a statement.

Naloxone is considered a major component of overdose prevention strategies. In recent years, most states have facilitated access to the antidote for laypeople. First responders, drug users, and others began to wear naloxone to reverse overdoses. But the price of drugs has been a problem for state and local governments.

Harm Reduction Therapeutics, based in Pittsburgh, says it's trying to put its release on the market in two years.

"Fighting the current crisis of opioid dependence will require innovative approaches to prevention and drug-assisted treatment," said Michael Hufford, co-founder and CEO of Harm Reduction. . "

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