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Researchers have developed an anti-inflammatory molecule that could lead to better treatments for diseases such as sepsis and potentially other autoimmune diseases.
"We have come up with a new drug molecule that inhibits inflammation," said lead author of the study, Thomas Helleday, of the Karolinska Institutet in Sweden.
This discovery is the result of many years of Helleday's research on how DNA is repaired by the body.
It's developing a new molecule to inhibit the enzyme that repairs the damage caused by oxygen to the DNA that researchers have discovered, to their surprise, that it also mitigated the # 39; ignition.
It turned out that the enzyme OGG1, in addition to repairing the DNA, also triggers inflammation.
The inhibitor blocks the release of inflammatory proteins, such as TNF alpha, says the study published in the journal Science.
When tested on mice with acute lung disease, the researchers successfully alleviated the inflammation.
The researchers found that the inhibitor was acting in a different way from other currently available anti-inflammatory drugs and could also help prevent the immune system from attacking it under conditions such as sepsis, multiple sclerosis, Crohn's disease and potentially other autoimmune disorders.
Inflammation is a process by which the white blood cells of the body protect us from infections, such as bacteria and viruses.
However, under certain conditions, the immune system triggers an inflammatory reaction when there is no infection to fight. This has the effect that the body's normally protective immune system damages its own tissues.
"When the regulation of oxygen in our cells goes wrong, it can damage our DNA and cause our immune system to respond," said Helleday, also affiliated with the University of Sheffield in Britain.
"Our immune system is our defense mechanism that normally fights invasions of bacteria and viruses, but it can sometimes cause misfires and attack our own body.
"Isolating an inhibitor that may disable this response is a major breakthrough and we are very excited to continue our research to see if we can not only reduce the existing inflammation in other regions of the world. body, but also prevent it.
"This would pave the way for new, effective treatments for life-threatening diseases such as sepsis," Helleday said.
–IANS
gb / sed
(This story has not been changed by Business Standard staff and is generated automatically from a syndicated feed.)
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