[ad_1]
Medical tests have shown that a bacterium causing gangrene, which can be harmful in high doses, could help treat patients with advanced cancer in case of failure of other options.
Safety tests on a new type of "bacterial treatment" revealed that tumors that became resistant to other treatments became necrotic and decreased when injected with bacterial spores.
Doctors at the University of Texas used a bacterial strain related to bacterial infection in the lethal hospital superbug Clostridium difficile, which has been modified to make it less harmful to humans.
Clostridium novyi-NT needs an environment containing very little oxygen to survive. it means that it will not grow in healthy tissue with a good blood supply, but that dense, fast-growing tumors are a perfect host.
"By exploiting the inherent differences between healthy and cancerous tissues, Clostridium novyi-NT represents a very precise cancer treatment that can specifically attack a patient's cancer," said Dr. Filip Janku of the University's Anderson Cancer Center. .
The bacteria could be particularly powerful in combination with a new generation of cancer treatments called immunotherapies, which stimulate the immune system to identify and attack tumors, he added.
The results are presented Sunday at the International Conference on Cancer Immunotherapy in New York and, although they have not yet been published in a scientific journal, they have already sparked new trials.
Potential new medical treatments require several rounds of human testing, first to verify their safety, then to prove that they routinely improve survival within large patient populations.
During the trials, Dr. Janku and his colleagues focused on what doses could be used safely.
They recruited 24 patients with solid tumors who became resistant to conventional chemotherapy and other treatments, and injected between 10,000 and three million bacterial spores.
The authors report that the two patients receiving the highest dose developed severe sepsis and "gas gangrene". As a result, the team identified a safe dose of one million spores in which the side effects were "manageable".
In the remaining 22 patients, the first results showed that the treatment had stopped growing and that in 23% of the cases, the size of the tumors had decreased by more than 10%.
1/14 Discovery of a new dinosaur species
The Ledumahadi Mafube has been walking about 200 million years ago in what is now South Africa. Recently discovered by a team of international scientists, he was the largest land animal of his time, weighing 12 tons and standing 13 feet. In Sesotho, the South African language of the region in which the dinosaur was discovered, its name means "a giant thunderbolt at dawn"
Viktor Radermacher / SWNS
2/14
Scientists witnessed the birth of a planet for the first time.
This spectacular image of the SPHERE instrument on ESO's very large telescope is the first clear image of a planet taken in the very act of training around the star. dwarf PDS 70. The planet stands out clearly, visible as a bright spot to the right of the star. center of the image, which is blackened by the coronagraph mask used to block the blinding light of the central star.
ESO / A. Müller et al
3/14 New human organ discovered that scientists previously lacked
The layers long considered dense, connective tissue are actually a series of fluid-filled compartments that researchers have called "interstitium."
These compartments lie beneath the skin, just like the intestines, lungs, blood vessels and muscles, and join together to form a network supported by a network of strong and flexible proteins.
Getty
4/14 An unknown society previously lived in the Amazon rainforest before the arrival of Europeans, according to archaeologists
Working in the Brazilian state of Mato Grosso, a team led by archaeologists from Exeter University has unearthed hundreds of villages hidden in the depths of the rainforest.
These excavations included evidence of fortifications and mysterious earthworks called geoglyphs.
José Iriarte
5/14 One in 10 people have traces of cocaine or heroin on fingerprints, according to a study
More than 1 in 10 people had traces of Class A drugs on their fingers, developing a new fingerprint-based test.
Using a sensitive analysis of the chemical composition of sweat, researchers were able to differentiate between those who had been directly exposed to heroin and cocaine and those who had indirectly encountered it.
Getty
6/14 NASA publishes breathtaking images of Jupiter's big red spot
The storm, bigger than the Earth, has been swirling for 350 years. The colors of the image have been improved after returning to Earth.
Pictures of: Tom Momary
7/14 A 3D reconstruction of an African Gray parrot after euthanasia
Included in the Wellcome Image Awards, this 3D image of a gray parrot from Africa shows the highly complex system of blood vessels.
Scott Birch. Wellcome Images
8/14 Hawaiian squid baby
Another winner of the Wellcome Images Award, this time from Hawaiian baby bobtail squid. The black ink bag and light organ in the center of the clam mantle cavity can be clearly seen.
Macroscopic solutions. Wellcome Images
9/14 Skeletons of 5,000-year-old Chinese giants have been discovered by archaeologists
People would have been exceptionally tall and strong. The largest skeleton discovered at 1.9 m
Youtube
10/14 NASA finds a 75,000 mile hole in the sun
Sunspots are caused by interactions with the Sun's magnetic field and are colder areas on the surface of the star.
Nasa
11/14 Display (active tab) Apple News Latest News E-mail Edit Revisions Workflow Clear Cache NewsScience Dinosaur Fossil of 132 Million Years Found at Surrey Factory
Paleontologists Sarah Moore and Jamie Jordan believe they have discovered an Iguanodon dinosaur, an herbivore about three meters tall and 10 meters long.
Cambridge Photographers / Wienerberger
12/14 The discovery of life on Mars is less likely because researchers find toxic chemicals on its surface
The Echus Chasma, one of the largest source areas of Mars water
Getty Images
13/14 The large prismatic spring, the largest in the United States and the third largest in the world, is visible in Yellowstone National Park.
The park is famous for its geothermal activity – which includes its spectacular hot springs as well as the famous "Old Faithful" geyser that sprays water just about every hour.
REUTERS / Jim Urquhart
14/14 An iris clip attached to the eye
This image is part of the Wellcome Images Awards and shows how an artificial intraocular lens is mounted on the eye. Used for conditions such as myopia and cataracts.
University Hospitals Cambridge NHS FT. Wellcome Images
1/14 Discovery of a new dinosaur species
The Ledumahadi Mafube has been walking about 200 million years ago in what is now South Africa. Recently discovered by a team of international scientists, he was the largest land animal of his time, weighing 12 tons and standing 13 feet. In Sesotho, the South African language of the region in which the dinosaur was discovered, its name means "a giant thunderbolt at dawn"
Viktor Radermacher / SWNS
2/14
Scientists witnessed the birth of a planet for the first time.
This spectacular image of the SPHERE instrument on ESO's very large telescope is the first clear image of a planet taken in the very act of training around the star. dwarf PDS 70. The planet stands out clearly, visible as a bright spot to the right of the star. center of the image, which is blackened by the coronagraph mask used to block the blinding light of the central star.
ESO / A. Müller et al
3/14 New human organ discovered that scientists previously lacked
The layers long considered dense, connective tissue are actually a series of fluid-filled compartments that researchers have called "interstitium."
These compartments lie beneath the skin, just like the intestines, lungs, blood vessels and muscles, and join together to form a network supported by a network of strong and flexible proteins.
Getty
4/14 An unknown society previously lived in the Amazon rainforest before the arrival of Europeans, according to archaeologists
Working in the Brazilian state of Mato Grosso, a team led by archaeologists from Exeter University has unearthed hundreds of villages hidden in the depths of the rainforest.
These excavations included evidence of fortifications and mysterious earthworks called geoglyphs.
José Iriarte
5/14 One in 10 people have traces of cocaine or heroin on fingerprints, according to a study
More than 1 in 10 people had traces of Class A drugs on their fingers, developing a new fingerprint-based test.
Using a sensitive analysis of the chemical composition of sweat, researchers were able to differentiate between those who had been directly exposed to heroin and cocaine and those who had indirectly encountered it.
Getty
6/14 NASA publishes breathtaking images of Jupiter's big red spot
The storm, bigger than the Earth, has been swirling for 350 years. The colors of the image have been improved after returning to Earth.
Pictures of: Tom Momary
7/14 A 3D reconstruction of an African Gray parrot after euthanasia
Included in the Wellcome Image Awards, this 3D image of a gray parrot from Africa shows the highly complex system of blood vessels.
Scott Birch. Wellcome Images
8/14 Hawaiian squid baby
Another winner of the Wellcome Images Award, this time from Hawaiian baby bobtail squid. The black ink bag and light organ in the center of the clam mantle cavity can be clearly seen.
Macroscopic solutions. Wellcome Images
9/14 Skeletons of 5,000-year-old Chinese giants have been discovered by archaeologists
People would have been exceptionally tall and strong. The largest skeleton discovered at 1.9 m
Youtube
10/14 NASA finds a 75,000 mile hole in the sun
Sunspots are caused by interactions with the Sun's magnetic field and are colder areas on the surface of the star.
Nasa
11/14 Display (active tab) Apple News Latest News E-mail Edit Revisions Workflow Clear Cache NewsScience Dinosaur Fossil of 132 Million Years Found at Surrey Factory
Paleontologists Sarah Moore and Jamie Jordan believe they have discovered an Iguanodon dinosaur, an herbivore about three meters tall and 10 meters long.
Cambridge Photographers / Wienerberger
12/14 The discovery of life on Mars is less likely because researchers find toxic chemicals on its surface
The Echus Chasma, one of the largest source areas of Mars water
Getty Images
13/14 The large prismatic spring, the largest in the United States and the third largest in the world, is visible in Yellowstone National Park.
The park is famous for its geothermal activity – which includes its spectacular hot springs as well as the famous "Old Faithful" geyser that sprays water just about every hour.
REUTERS / Jim Urquhart
14/14 An iris clip attached to the eye
This image is part of the Wellcome Images Awards and shows how an artificial intraocular lens is mounted on the eye. Used for conditions such as myopia and cataracts.
University Hospitals Cambridge NHS FT. Wellcome Images
However, the final reduction of the tumor could be even greater, said Dr. Janku, because the treatment initially causes inflammation and swells the tumor with the immune cells that attack it.
This method of treatment has two advantages: in 46% of cases, the bacterial spores germinated and began to multiply, rapidly causing necrosis and cell death in the tumor; However, even when the spores have not developed, due to lack of oxygen or other conditions, the presence of these bacterial spores has helped the immune system to wake up and attack the tumor.
"From these preliminary results, it appears that Clostridium novyi-NT is able to activate the immune response in addition to causing tumor destruction," added Dr. Janku.
"We were extremely encouraged by the results of this trial, especially in patients with advanced sarcomas, where immunotherapy has not been proven effective.
"This bacteriolytic strategy could be clinically significant, particularly in combination with checkpoint inhibitors, for patients with advanced solid tumors."
Source link
