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A new antibiotic that acts as a "Trojan Horse" has been shown to be effective against drug-resistant bacteria, researchers said.
Scientists have reported that clinical trials of 448 people with kidney and urinary tract infections have shown that the drug, a cefiderocol, has eliminated germs just as effectively as current treatments.
The drug alters the biology of the bacteria by binding to iron to enter cells – like the Trojan horse that was used to move ancient Greeks into the city of Troy.
Experts say the research findings highlight the potential of cefiderocol as a new option for the treatment of highly resistant bacteria.
Dr. Simon Portsmouth of Shionogi Inc., Director of Research, said, "It has been found that cefiderocol is both safe and tolerable in a population of elderly patients with very complex diseases and a wide range of patients. Multidrug-resistant pathogens.
"Our results support cefiderocol as a new approach that could be used to overcome negative gram resistance."
Cefiderocol was found to be both safe and tolerable in a population of elderly patients who were very sick with complex conditions
The drug, he says, takes advantage of the iron's need for iron to survive by binding to iron, which carries it beyond the defenses of the bacteria and into its cells.
The results, published in The Lancet Infectious Diseases, are part of the growing threat of human resistance to antibiotics, described as the most urgent threat to public health by health professionals.
Earlier this week, a new report detailed that blood infections caused by insects resistant to one or more key antibiotics had increased by 35% in just four years.
Public Health England (PHE) calculated that if antibiotics became ineffective, three million operations and cancer treatments would threaten the patient's life.
Trials are underway to study the effectiveness of cefiderocol against pneumonia and infections resistant to some of the most potent drugs, carbapenems.– Press Association
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