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The team of researchers reports promising results in preclinical models.
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A new study by researchers at Brigham and Women's hospitals explores the potential of gene editing to use cancer cells in the fight against cancer.
The team of researchers presents promising results in preclinical models of several types of cancer cells and has published their findings in Science Translation Medicine.
"This is just the tip of the iceberg," said corresponding author Khalid Shah MS, PhD, director of the Stem Cell Therapy and Imaging Center at BUR's Department of Neurosurgery at EurekAlert. "Cell therapies are extremely promising for the administration of therapeutic agents to tumors and can offer treatment options in the event of standard treatment failure. With our technique, we show that it It is possible to reverse engineer cancer cells of a patient and use them to treat cancer.We think this has many implications and could apply to all types of cancer cells. "
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By harnessing the power of self-homing cancer cells, a process by which cancer cells can track cells of this type that have spread in the same organ or in other parts of the body, researchers think that they will be able to overcome the drug delivery. challenges.
The team has developed and tested two techniques to use the power of cancer cells.
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To test both approaches, the team used mouse models of primitive and recurrent brain cancers, as well as breast cancers that spread to the brain.
The reconfigured cancer cells targeted and killed recurrent and metastatic cancers in the mice and increased the survival rate of the mice.
"Our study demonstrates the therapeutic potential of using modified tumor cells and their self-hosting properties for the development of targeted receptor therapies for various cancers," Shah said, according to EurekAlert.
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