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In a first study of this type, researchers discovered that a common chemical that consumers are exposed to several times a day can alter insulin release. The results of the study, conducted by scientists at the University of Missouri, indicate that the daily intake of BPA approved by the Food and Drug Administration may be sufficient to have consequences on the development of type 2 diabetes and other metabolic diseases.
"Bisphenol A is an endocrine disrupting chemical used in the manufacture of thermal paper, plastics and a wide range of consumer products," said Frederick vom Saal, endocrinologist and divisional curator professor. of the biological sciences of the MU College of Arts. and Science, and co-author of the study. "Experiments with human and murine pancreatic cells revealed that a low dose of BPA exposure, in the presence of glucose, triggers an insulin response. We wanted to test the potential effects of BPA." in the man to see if this remains true. "
In both studies, subjects received orally a safe dose of BPA, which led to the same amount of BPA in their blood that customers might encounter by handling a cash receipt; or, the same subjects received placebo exposure for comparison. Responses to insulin were then assessed by an oral glucose tolerance test in the first experiment or a hyperglycemic clamp in the second experiment. The results of both studies showed that BPA impaired insulin release compared with placebo exposure in subjects. In studies in animals, repeated exposure to BPA resulted in insulin resistance.
"This exploratory study needs to be replicated as it suggests that exposure to BPA at a dose considered safe by US regulators could alter responses to glucose-stimulated insulin in humans," said vom Saal. "Our study is a first step in determining whether exposure to endocrine-disrupting chemicals, such as BPA, contributes to insulin resistance and, possibly, to type 2 diabetes."
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Material provided by University of Missouri-Columbia. Note: Content can be changed for style and length.
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