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Examining stress and inflammation in the heart can be critical in predicting the risk of Parkinson's disease, say the researchers, as this could help doctors test new therapies and delay the progression of the disorder
. About 60% of patients with Parkinson's disease are diagnosed – usually because of tremors and motor symptoms – and are severely affected by sympathetic nervous system connections.
When they are healthy, these nerves stimulate the heart. pumping to match the rapid changes in activity and blood pressure.
"This neural degeneration in the heart means that patients' bodies are less prepared to respond to stress and simple changes such as getting up, they have increased the risk of fatigue, fainting and fainting. fall that can cause injury and complicate other symptoms of the disease, "said Marina Emborg, of the University of Wisconsin-Madison, USA.
For the study, published in the journal npj Parkinson Disease, the teams used Rhesus macaque monkeys as models for the symptoms of Parkinson's disease, who received doses of neurotoxins that damaged nerves in their hearts in the same way as Parkinson's disease affects human patients.
and the progression of the potential causes of such damage, radioligands can also be used to test the efficacy of new treatments to protect neurons q which regulate the activity of the heart of patients.
"We know that there is damage in the heart in Parkinson's patients, but we have not been able to see exactly what causes it.Now we can visualize in detail where Inflammation and oxidative stress occur in the heart, and how it relates to how Parkinson's patients lose these neuronal connections in the heart, "said lead author Jeanette Metzger. 15, 2018 8:40
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