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No. 1 Alabama and No. 2 Clemsons are both heavy games in their respective games on Saturday, but if we've learned anything over the years, it's that major upsets can occur at any time down the stretch of the season. Key games in the races for the Big Ten ACC, Big 12 and SEC titles – a couple College football Playoff bids, of course – go down -time rivals. There is plenty to digest and dive into as many upsets are bound to go down. Who will be getting knocked off? That remains to be seen, but we should find out soon.
With action beginning early in the day and continuing late into the evening, let's take a look at the biggest games on the schedule. Our CBS Sports college football experts have picked each game both up and down the spread, giving you ample opportunity to decide how to make your picks ahead of kickoff.
All times Eastern
No. 10 Ohio State (-3.5) at No. 18 Michigan State – noon on FOX, fuboTV (Try for free): You might think Ohio State should not be favored on this road Michigan state team, but what if I told you that Ohio State has not lost to Michigan State in East Lansing since 1999? That's right, the Buckeyes have won six straight at Spartan Stadium. And while this is an Ohio State team that has plenty of concerns about defense, unlike Purdue and Nebraska, I do not believe Michigan State has an offense capable of exploiting them. I do not know if this is a "get right" game for the Buckeyes, but I do not think it's a spread they'll cover. Pick: Ohio State -3.5 – Tom Fornelli
No. 1 Alabama (-24.5) at No. 16 Mississippi State – 3:30 p.m. on CBS, CBSSports.com: After a one-week hiatus, at least in theory, we're back to playing college football's most popular game: "Will Alabama Cover?" This week, the answer is "yes." It's a thing for Nick Fitzgerald to look like a complete quarterback against Texas A & M and Louisiana Tech, but it's a completely different thing to do against the Crimson Tide. The defensive line will go down the run with just one, the defense will dominate in the passing game, and Tua Tagovailoa will have another heisman-worthy game in a big home win. Pick: Alabama -24.5 – Barrett Sallee
So which teams should you back in Week 11 of the college football season? And what playoff contender will get a huge scare? Visit SportsLine now to see the score for each single FBS matchup, from the model that has returned over $ 4,000 in profit to $ 100 bettors over the last three seasons.
Oklahoma State at No. 6 Oklahoma (-17.5) – 3:30 p.m. on ABC: Oklahoma State has already shown it can play for a game when the situation calls for it, but can it do it twice? Everything went right in the win over Texas, but the Cowboys will have their best game – and their best defense – of the season to hang with Oklahoma. Pick: Oklahoma -17.5 – Ben Kercheval
No. 24 Auburn at No. 5 Georgia (-14) – 7 p.m. on ESPN: You can not predict exactly what will happen in rivalry games, but The Bulldogs will shut down Auburn's putrid rushing attack and force Jarrett Stidham into some dicey situations against a tough pass defense. Stidham's goal has been improved over the last couple of games, and will have enough success to keep the Bulldogs sweating. Swift, Elijah Holyfield and the rest of the rake attack will wear the Tigers and pull away in the fourth quarter to notch a win – just not a cover. Pick: Auburn +14 – Barrett Sallee
No. 2 Clemson (-20) at No. 17 Boston College – 8 pp. On ABC: There are so many things to do about the "best" Clemson team of all time without a doubt that they lived in the glory of the Frank Howard years, but I think it is fair to say that this is the most dominant Clemson team we 've ever seen. Like its rival playoff Alabama, you can not be sure that I will not take the Tigers to cover right now. Pick: Clemson -20 – Chip Patterson
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