Discovery of an ancient genetic mechanism to facilitate treatment: study



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Discovery of an ancient genetic mechanism to facilitate treatment: study








outlookindia.com

1970-01-01T05: 30: 00 + 0530

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Sydney, November 25 – Researchers have uncovered new evidence for the advanced regulation of DNA in an ancient marine organism, revealing that crucial mechanisms of gene activation and deactivation could have their origin much earlier than expected, a discovery that suggests a better understanding of genetic processes and treatment of diseases.

The study, co-led by Australian researchers, analyzed Amphioxus DNA and uncovered the "tricks" used to control gene expression, which could come much earlier than expected, according to the report. Xinhua News Agency quoted by the Garvan Institute of Medical Research in Australia.

The translucent, fish-like organism was "just on the verge of vertebrate-invertebrate" and was "perfectly positioned to help us understand how our genomes have made the leap from an invertebrate to a vertebrate", said the main author Ozren Bogdanovic of the institute.

"With Amphioxus, one of the closest invertebrates to humans, which is almost a vertebrate but not quite," he added.

The old body helped to highlight, for the first time, regions used to regulate gene expression in an invertebrate species, he noted, in the report. article published in the journal Nature.

"It tells us that this regulatory mechanism could have appeared millions of years ago," he said. "And that tells us a lot about the evolution of DNA regulation, but also helps us better understand how it works in more complex organisms, like us."

The next step in the study is to continue studying the link between vertebrates and invertebrates, to better understand the regulation of DNA, said Bogdanovic.

"This will allow us to deepen our understanding of the functioning of DNA regulation, and in particular of its dysfunction in diseases, understanding these processes could help us better understand and ultimately treat diseases." , did he declare.

rt / mag / sed

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