Exercise can delay cognitive decline in people with rare Alzheimer's disease

According to a new study available online at the company, individuals with a genetic mutation causing Alzheimer's disease, practicing at least 2.5 hours of physical activity a week can have beneficial effects on the markers of Alzheimer's disease. Alzheimer. Alzheimer's and dementia: the journal of the Alzheimer's association as an article in press, proof corrected.

According to the authors, these findings confirm the benefit of physical activity on the progression of cognition and dementia, even in people with autosomal dominant Alzheimer's disease, a rare form of the disease characterized by the development of a relatively young dementia. age is inevitable.

The authors say their findings "show a significant relationship between physical activity, cognition, functional status, and pathology of Alzheimer's disease, even in people with genetically modified ADAD." Public health, 70% of all ADAD patients participating in the DIAN study have reached this level of physical activity, so that a physically active lifestyle is feasible and can play an important role. development and progress of ADAD. "

"The results of this study are encouraging, and not just for people with Alzheimer's disease of rare genetic origin," said Maria C. Carrillo, Ph.D., Scientific Director from the Alzheimer's Association. "If further research confirms this relationship between physical activity and the late onset of dementia symptoms in ADAD, we need to expand the scope of this work to see if this is also true in millions of people. of people with late onset Alzheimer's. "

Christoph Laske, MD and his research team at Tübingen University Hospital, Germany, analyzed the data generated by 275 individuals (mean age 38.4 years) with a genetic mutation for ADAD and participating in the DIAN international network. Study of individuals and families with ADAD conducted by researchers from the University of Washington's School of Medicine in St. Louis.

The researchers aimed to determine if at least 150 minutes of physical activity (walking, running, swimming, aerobics, etc.) per week – the current recommendation of the World Health Organization and the World Health Organization. American College of Sports Medicine – would produce cognitive benefits for the study participants One hundred and fifty-six (156) people were classified as having high physical activity (> 150 minutes of physical activity / week); 68 people who are not very active in physical activity (

The researchers found that people who engaged in more physical activity scored better on Mental State of the Mind (MMSE) and Clinical Sum of Dementia Ratings (CDR-SOB), standard measures. well accepted cognition and function. Similarly, people who have exercised more have lower levels of biomarkers of Alzheimer's disease in the cerebrospinal fluid, including a lower tau, a protein that accumulates in people's brains with Alzheimer's disease. However, the individual trajectories of cognitive changes have not been evaluated in this cross-sectional study.

"A physically active lifestyle is feasible and can play an important role in delaying the development and progression of ADD," said the authors of the study, concluding that people with genetic risk of dementia should be counseled to an active life. "

"There is a growing body of scientific evidence of the beneficial impact of lifestyle factors on reducing the risk of cognitive decline and dementia, or even prevention," Carrillo said. "For example, at the 2018 AAIC in July, we heard preliminary results from SPRINT MIND, the first randomized clinical trial to demonstrate that an intensive blood pressure treatment reduces new mild cognitive disorders and the combined risk of MCI dementia.This adds credibility to the vision of future therapy for Alzheimer's disease, which combines drugs and modifiable interventions on risk factors, as we currently do for heart disease .

To generate scientific evidence on the effects of lifestyle on brain health, the Alzheimer's Association is currently conducting a large two-year clinical trial called the American Study for the Protection of Brain Health through a risk-reducing intervention. . The study is a two-year clinical trial to assess whether lifestyle-oriented interventions that simultaneously target multiple risk factors protect cognitive function in older adults at increased risk of cognitive decline. US POINTER is the first study of its kind done in a large group of Americans across the United States.

"The relationship between physical activity, cognition and Alzheimer's pathology in autosomal dominant Alzheimer's disease", by Dr. Stephan Muller et al., Was supported by the German Alzheimer's Disease Network Center Neurodegenerative Diseases (DZNE), Raul Carrea Neurological Research Institute (FLENI), Japan Agency for Medical Research and Development, AMED, and Korea Institute of Health Industry Development (KHIDI).

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