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October 12, 2018
Variability in fasting blood glucose has been shown to be a risk factor for the development of type 2 diabetes.
Greater Variation in Fasting Plasma Glycemia Over Time Is Associated With Increased Risk Of Type 2 Diabetes, According to a Study Published in Diabetic treatments.
Researchers analyzed data from the Korean national health insurance system on 131,744 non-diabetic participants initially for fasting plasma glucose levels and the development of type 2 diabetes over a median follow-up period of 8.3 years. The database contained information on medical history, ICD-10 codes, health variables, questionnaires, blood tests and laboratory tests.
The fasting plasma glucose variation coefficient, the standard deviation, and the mean independent variability were used to calculate the fasting plasma glucose variability. Type 2 diabetes was defined as a fasting plasma glucose level ≥ 7 mmol / L, while glucose impairment was defined as a fasting plasma glucose level between 5.6 mmol / L and 6.9 mmol / L.
Overall, participants with higher plasma fasting glucose variation were older men who smoked, drank, had little physical activity, and had a higher rate of hypertension and dyslipidemia. After adjusting for the confounding variables, the risk ratio for the fasting glucose plasma variation coefficient was 1.24 (95% CI, 1.22 to 1.27; P <0.001). In addition, the risk ratio for the standard deviation of fasting glucose was 1.23 (95% CI, 1.20 to 1.25; P <0.001) and the ratio of variability of fasting glucose regardless of the mean was 1.23 (95% CI, 1.21-1.26; P <0.001). For the fasting plasma glucose coefficient of variation, an increase of 1 standard deviation resulted in a 24% increase in the risk of type 2 diabetes.
The investigators recommended that future studies include a more diverse population to get other results, use other diagnostic tools for diabetes, such as oral glucose tolerance tests or results of 39, HbA1c, and include eating behaviors as a variable.
The researchers concluded that "there were clear associations of [fasting glucose plasma] variability with increased risk [for] type 2 diabetes "independently of other confounders.
Reference
Kim JA, Lee JS, Chung HS et al. Impact of fasting plasma glucose variability from visit to visit on the development of type 2 diabetes: a nationwide cohort study [published online Sept. 25, 2018]. Diabetic treatments. doi: 10.2337 / dc18-0802
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