Fisetin – the natural way to stop aging, increase longevity

A natural product has been discovered that reduces the level of damaged cells in the body, caused by aging

Researchers at the Minnesota Medical University showed that the treatment of elderly mice with the natural product Fisetin had significant positive effects on health and shelf life. Fisetin is found in many fruits and vegetables.

As you get older, people accumulate damaged cells. When cells reach a certain level of damage, they go through their own process of aging, called cellular senescence. The cells also release inflammatory factors that invite the immune system to clean up damaged cells.

The immune system of a younger person is healthy and is able to clean up damaged cells. But as people get older, they are not eliminated as effectively. Thus, they begin to accumulate, cause low intensity inflammation and release enzymes that can degrade the tissues.

Previous research published earlier this year in Medicine of nature, shown that damaged cells, called senescent cells, can cause physical dysfunction and decreased survival even in young mice, while senolytics can improve the health and life span of older mice.

This is the first demonstration that shows the effects of the drug on specific subsets of these damaged cells in a given tissue.

The researchers discovered a natural product, called Fisetin, which has senotherapeutic activity in mice and human tissues. he reduces the level of these damaged cells in the body. They found that treating mice at the end of life with this compound improved their health and life span. The paper, "Fisetin is a senotherapeutic drug that prolongs health and longevity, "Was recently published in EBioMedicine.

"These findings suggest that we can extend the health period, called healthspan, even towards the end of life," said the study's author. Paul D. Robbins. "But there are still many issues to be resolved, including the right mix, for example." The team used mass cytometry technology, or CyTOF, for its research work.

"In addition to showing that the drug works, it is the first demonstration of its effects on specific subsets of these damaged cells in a given tissue., " Robbins added.

These features suggest that Fisetin may be subject to clinical trials on humans.