[ad_1]
The study was published in the Journal of Cell
Image of representation
New study found that the gut microbiota, which is the complex community of microorganisms that live in the digestive tract of humans and other animals, can alter the behavior of cells in response to insulin and thus contribute to diabetes type 2.
The study was published in the Journal of Cell. Scientists from the Sahlgrenska Academy of the University of Gothenburg, Sweden, have shown that the intestinal microbiota of people with type 2 diabetes mellitus-naive treatment may be linked to a different metabolism of histidine, a amino acid mainly derived from the diet.
In recent years, the gut microbiota has been associated with health and several diseases. However, only a few studies have examined whether an altered gut microbiota can directly affect the disease.
This leads to the formation of imidazole propionate, a substance that impairs the ability of cells to respond to insulin.
Reducing the amount of imidazole propionate produced by bacteria could therefore be a new way of treating patients with type 2 diabetes.
"This substance does not cause all type 2 diabetes, but our working hypothesis is that there are subpopulations of patients who could benefit from a dietary change or modification of their microbiota." intestinal to reduce levels of imidazole propionate, "said Fredrik Backhed, a professor at Molecular. A medicine focused on the role of the gut microbiota in metabolism.
The latest study included the analysis of various substances in the blood vessel ranging from the intestine to the liver. The researchers then identified a high concentration of imidazole propionate in patients with type 2 diabetes.
With the help of fecal samples, it was also possible to show that the microbiota of people with type 2 diabetes produced imidazole propionate when histidine was added. This mechanism was not found in control subjects without diabetes.
The study included five patients with type 2 diabetes and 10 control subjects without diabetes. The results were then confirmed in a larger study involving 649 people.
The scientists from Gothenburg then studied the effect of imidazole propionate on sugar metabolism and discovered that the molecule affected a signaling pathway previously linked to metabolic-related diseases by directly activating a specific protein, p38gamma.
These results provided answers to questions about the nature of the underlying mechanisms. According to Backhed, these often remain unanswered in studies of how intestinal bacteria are associated with, for example, obesity, diabetes, and cardiovascular disease.
"Our results clearly show how important the interaction between gut microbiota and diet is to understand our metabolism, whether it's health or disease. The result also shows that Intestinal bacteria from different individuals can lead to the production of completely different substances that can have very specific effects on human beings, the body, "said Backhed.
Catch up on all the news Crime, national news, international and Hatke right here. Download also the new mid-day Android and iOS apps to get the latest updates
This story was extracted from an outsourced third party, the agencies. With the exception of the title change, the story has been provided "AS IS", "AS AVAILABLE, WITHOUT ANY VERIFICATION OR RELEASE FROM OUR PARTY." Mid-day accepts no responsibility for its reliability, reliability, reliability and data Mid-day management / mid-day.com reserves the exclusive right to modify, delete or delete (without notice) the content, in its sole discretion, for any reason whatsoever .
Source link
