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MedicalResearch.com Interview with:
Dr. Po-Hong Liu
Stuart Po-Hong Liu, MD, MPH
Clinical and Translational Epidemiology Unit Massachusetts General Hospital and
Harvard Medical School
Boston
MedicalResearch.com: What is the context of this study?
Reply: Although the overall incidence of colorectal cancer (CRC) has declined overall, colorectal cancer rates have increased dramatically in the 20-49 age group in the United States, parts of Europe, and Asia. . The etiology and early detection of the onset of young people become an emerging research and clinical priority. Another important fact, namely that this emerging public health problem, has resulted in the update of the American Cancer Society guidelines recommending that average risk screening be started at age 45 rather than at age 50. years.
However, until now, the etiology of the appearing young CRC remains largely unknown. The elucidation of the role of traditional CRC risk factors in the etiogenesis of young CRC appears as one of the first research programs.
MedicalResearch.com: What are the main conclusions?
Reply:In this large prospective study of women, we found that a higher current BMI was associated with an increased risk of colorectal cancer at an early stage. BMI at 18 and weight gain since the age of 18 contributed to this observation.
MedicalResearch.com: What should the readers of your report keep?
Reply: First of all, our results require validations in other studies. If validated, the implications could be multiple:
1) Physicians should be more aware of the potentially higher risk of early-onset colorectal cancer in their overweight and obese younger patients, and ensure that they undergo screening at age 45, in accordance with the latest directives
2) On the other hand, obese young adults should be educated and aware of their higher risk of colorectal cancer at a younger age. Our results reinforce the benefits of controlling obesity in young adults and throughout their lives.
Disclosures: Dr. Po-Hong Liu and Dr. Yin Cao have nothing to disclose. Some authors have received consulting fees from Janssen, Pfizer Inc. and Bayer Healthcare A.G.
Quote:
Liu P, Wu K, Ng K, et al. Association of obesity with the risk of colorectal cancer at an early stage in women. JAMA Oncol. Posted online 11th of October 2018. doi: 10.1001 / jamaoncol.2018.4280
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