HIV / AIDS treatment drastically reduces mortality and helps to limit transmission

There's still no cure and no vaccine. People still die from it. It is still being transmitted in some parts of the world (sub-Saharan Africa) and in some sections of the United States (the Southeast).

And yet, and yet …

There's no getting around it: Deaths from HIV / AIDS plummeted from a high in the United States of 41,699 in 1995 to 6,456 in 2015 (the latest year for which statistics are available). HIV / AIDS treatment is a health care success story. In 1994, HIV / AIDS became the leading cause of death for Americans aged 25 to 44. About 675,000 people in the United States Morbidity and Mortality Weekly Report in 1981. Robert Redfield, CDC director and a trainer AIDS researcher. "I think it could be done in the next three to seven years, if we put our mind to it," he said in March.

And on an individual basis, the message to a patient is entirely different and an optimistic one. "We can literally say to some people that they are newly diagnosed with HIV," says Paul E. Sax, MD, the clinical director. of the HIV program and division of infectious diseases at Brigham and Women's Hospital in Boston. "And that they can live as long as a person who is HIV negative."

The first breakthrough came in 1987 with AZT, the first FDA-approved antiretroviral drug to show some effectiveness against HIV though it had some serious side effects, including anemia. In 1995 the FDA approved the first protease inhibitor, saquinavir, which was followed by approvals of ritonavir and indinavir. They use highly effective antiretroviral therapy (HAART). By 1997, HAART became the new standard of care, and AIDS-related deaths declined 47% in 1997 compared with 1996.

David Hardy, MD, an AIDS researcher at George Washington University. The obvious example, he says, are the antiviral drugs for hepatitis C.

Paul E. Sax, MD

So why are not there an annual victory parades? For one thing, the slow response of the government at the beginning of the epidemic means many people suffered and died. And there's danger in complacency, notes Sax. "Because with infectious diseases, if you turn your back on them, you can not provide enough resources and support, they can come roaring back."

Transmission of HIV remains a major public health concern. Condoms help. Adherence to HIV / AIDS treatment the risk of transmission by people who are infected. Pre-exposure prophylaxis (PrEP) is another tactic that is at risk, but is not yet, infected. The PrEP regimen involves taking daily doses of tenofovir and emtricitabine (they are combined into a pill and sold to the brand-name drug Truvada). According to the CDC, it can reduce the risk of acquiring an HIV infection by 92%.

"You know for people who are expecting a clinic and are in good faith," says Sax. For many of his patients, it's like clockwork. "They're the kind of people who, when they change time zones, they still take their medications at the same time. But there is a small set of people who can not get it together to take medicine. And that's one of the challenges. Getting those people on care seems to be difficult. "

Another challenge is caring for people with HIV / AIDS in their later years. They have higher rates of heart disease, mostly, but also stroke, diabetes, liver disease, and kidney disease. "This may be a result of the medications, or may be a result of the long-term infections," says Hardy. It's a point made in April in a Washington Post story about this problem.

More study is needed. Now, as Hardy puts it, we still do not know for sure.

We do not know for sure because HIV-infected people are not living long enough to be able to provide services. And that brings us back to where we started.

"It's really astounding," says Sax, of the evolution of HIV / AIDS from a death sentence to a treatable, chronic condition. "It's one of the great success stories in the history of medicine."