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Washington- The National Cancer Institute of the United States awarded the Outstanding Investigator Award to Professor Arul Chinnaiyan of the University of Michigan and $ 6.5 million over seven years to identify cancer biomarkers for Improve diagnosis and develop new targeted therapies.
"The field of precision oncology continues to evolve with the overarching goal of providing cancer patients with improved diagnostic and prognostic capabilities and better treatments," Chinnaiyan said in a statement. communiqué, Monday evening.
"This grant will help us identify new biomarkers and understand their biological roles in cancer progression," he added.
A pioneer of precision oncology, Chinnaiyan in 2010, launched the Michigan Oncology Sequencing Program (Mi-ONCOSEQ).
Mi-ONCOSEQ is a research protocol for DNA and RNA sequencing of metastatic cancers and normal tissues to identify alterations that may promote treatment.
The program includes a table of precision tumors in which experts discuss each case.
Chinnaiyan's laboratory also analyzed the global landscape of a part of the genome that has not been well explored before – long non-coding RNAs (lncRNAs).
Earlier, considered as dark matter, new evidence suggests that lncRNAs may play a role in cancer and that their better understanding could lead to potential new targets for improving the diagnosis, prognosis or treatment of cancer.
Chinnaiyan's laboratory has also identified and explored several lncRNs that could be promising targets for future therapy.
"We want to further characterize the dark matter of the genome. Some of these lncRNs will certainly be very useful as cancer biomarkers and we believe that a subset is important in biological processes, "noted Chinnaiyan.
"We hope patients will have a molecular plan of their tumor to guide treatment choices." (IANS)
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