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The combination of aging and the consumption of high-fat and high-sugar foods has been associated with markers of Alzheimer's disease in one study.
Alzheimer's disease, the most common form of dementia, is the sixth leading cause of death in the United States: about 5.7 million Americans live with the disease, and this figure is expected to reach nearly 14 million in 2020.
But the cause of the disease remains unknown. The chance of developing it increases as we get older, and evidence suggests that diet-induced obesity could also be a risk factor, the authors of the new study published in the journal Physiological Reports noted .
To study these theories, researchers at Brock University in Ontario (Canada) administered a group of mice a diet high in fat and sugar, while a control group continued to eat normally.
After 13 weeks, scientists have measured levels of inflammation and stress in the hippocampus and the prefrontal cortex of mice.The hippocampus is related to memory formation and spatial awareness, while the prefrontal cortex is the part of the brain responsible for complex cognitive behavior. Areas could therefore contribute to the development of Alzheimer's disease.
The researchers found that mice fed a diet high in fat and sugar had significantly higher markers of insulin resistance, inflammation, and cellular stress in parts of the body. 39; hippocampus. play a role in Alzheimer's disease. The prefrontal cortex, meanwhile, showed signs of insulin resistance, but no change in cellular stress or inflammation. Aging also appears to be a factor, since levels of inflammation in the control group also increased in the control group compared to baseline readings, according to the study.
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The authors therefore believe that the combination of a diet high in fat and sugar aggravates the effects of aging on the brain by report to Alzheimer's Disease
"These findings add to our basic understanding of the pathways involved in the early development, progression of pathogenesis [Alzheimer’s] and demonstrate the negative effects of the disease. a HFS diet on both the prefrontal cortex and the hippocampal regions, "the authors said in a statement.
As the study was conducted on mice, further research is needed to understand if the results would be replicated in humans. But mouse models provide a useful insight into the mechanisms in the body.
This is the latest study to suggest that our diets might play a role in the onset of Alzheimer's disease. Earlier in June, a study by researchers at the University of Illinois at Chicago found that excessive consumption of alcohol could affect how the brain removes white blood cells associated with the Alzheimer's disease.
Journal of Neuroinflammation The suggested microglial cells, found in the central nervous system, have been prevented in their ability to eliminate beta-amyloid by levels of alcohol comparable to those from excessive consumption of alcohol.
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