Mortality from Non-Obesity-Related Higher Cancer in T2D Patients

BERLIN – Both men and women with type 2 diabetes are at a greater risk of dying from non-obesity-related cancers, being found in UK population-based study investigating associations between type 2 diabetes, body mass index (BMI), and cancer mortality.

Presenting at the European Association for the Study of Diabetes (EASD) 2018, Miss Nasra Alam, a colorectal surgeon in the North West of England currently undertaking a PhD at the University of Manchester, also looked at the relationship between increasing BMI and cancer mortality. "No consistent relationship is with diabetes," she told Medscape News UK.

But she expressed her surprise at the finding of unexpectedly high mortality of non-obesity-related cancers in patients with type 2 diabetes, which was higher in women than men. "These results suggest that these mechanisms are more likely to result from these non-obesity-related cancer deaths."

Role of Obesity and Non-Obesity Related Cancer in T2D

Patients with type 2 diabetes are known to have a higher risk of dying from cancer. "I wanted to look specifically at the role of BMI in this," remarked Alam. "Thirteen cancers are reported to be obesity-related cancers, and given the links between weight and type 2 diabetes, it makes sense to ask for these increased risks of these cancers."

Essentially, Alam, et al., Et al., Et al. BMI and cancer mortality in patients with type 2 diabetes.

Data were sourced on almost 176,886 patients with type 2 diabetes drawn from the Clinical Practice Research Datalink (CPRD), which derived data from 8% of GP practices across the UK. Patients were matched with 852,946 controls without type 2 diabetes.

Obesity-related cancers included in the analysis were post-menopausal breast, endometrial, ovarian, colorectal, kidney, pancreatic and liver, gallbladder, gastric cardia, oesophageal adenocarcinoma, meningioma, multiple myeloma, and thyroid cancers.

The analysis found that a total of 9606 people with 2 diabetes died of cancer between 1998-2015. In men, it was found that the total risk of death from any cancer was 22%; with obesity-related cancers, risk of death was 84%; and with non-obesity-related cancers, risk of death was 6%. "The 84% risk of death with obesity-related cancers makes sense of reality." But we do not expect to see the increase in non-obesity-related cancer deaths. women have type 2 diabetes they are more likely to die of non-obesity-related cancer than anyone without type 2 diabetes. "

In women, obesity-related cancers, and non-obesity-related cancers, were 31%, 47%, and 18% respectively. "The non-obesity-related cancer risk was a lot higher in men than in men," Alam pointed out.

With respect to BMI and cancer mortality in patients with diabetes mellitus, Alam found that 145,769 patients with BMI were diagnosed with diabetes mellitus, noncancer-related or non-obesity-related cancer deaths . "However, when we broke down the results by individual cancer type, there were some patterns." For example, endometrial cancer showed that your BMI was between 35 and 40 kg / m², you are at risk of endometrial cancer if you have diabetes compared to type 2 diabetes of normal weight. "

Commenting on the results, Dr. Soffia Gudbjornsdottir, from the University of Gothenburg, Sweden, said: "It was a large and well-conducted study.The increased risk of obesity-related cancer in those with diabetes It is important but it is important because it is important because it is important because it is so important that it is important because it is so prevalent. interesting with respect to the potential causal mechanisms here, and we need to study this more. "

IOC: Miss Alam and Dr Gudbjornsdottir have declared no relevant conflicts of interest.

Presented at EASD 2018. Abstract 1117. Wednesday, October 2, 2018.