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Non-small cell lung cancer is often fatal, as most cases are diagnosed only if advanced surgery is no longer possible.
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Researchers have developed a new technology that can detect lung cancer at an early stage, when surgical healing is possible.
The new technology (EFIRM) detects two epidermal growth factor receptor (EGFR) mutations associated with lung cancer in the blood of patients with non-small cell lung cancer (NSCLC) stage disease.
Non-small cell lung cancer is often fatal, as most cases are diagnosed only if advanced surgery is no longer possible.
The new technology tests the blood or saliva of patients with early-stage lung cancer to identify two cancer-related mutations, suggests a study published in The Journal of Molecular Diagnostics.
"The revolutionary EFIRM technology is the most exciting development of noninvasive liquid biopsy in recent years," said co-author Charles M. Strom of the University of California at Los Angeles (UCLA).
"The ability to detect early-stage lung cancer patients with an affordable blood or saliva test could save thousands, if not tens of thousands of lives each year around the world," said Strom.
For the study, the team collected plasma samples from 248 patients. Of these, 44 were diagnosed with stage I or II NSCLC.
"Currently, the clinical sensitivity of EFIRM to detect patients with NSCLC is limited by the percentage of tumors containing either or both of the variants, which is estimated at 27% of tumors. of NSCLC, "explained co-author, Wu-Chou Su the Medical College of Cheng Kung National University in Taiwan.
"We are currently developing a panel of 10 variants containing detectable mutations expressed in 50% of lung malignancies," Su said.
The research team pointed out that this study did not present direct evidence that the detection of EGFR mutations in the plasma of an individual predicted that the patient had cancer.
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