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Scientists have developed a sustainable way to generate molecules that enable the design of new types of synthetic drugs.
Researchers at Ohio State University in the United States have said that this new method of forming reactive intermediates, called cetyl radicals, provides a way to use catalysts to convert single molecules. in complex structures into a single chemical reaction.
According to a study published in the journal Science, this is done in a less severe, more sustainable and less wasted way.
"The previous strategy for creating cetyl radicals was about a century old.We found a complementary way to access cetyl radicals by using LED lights for the synthesis of complex molecules resembling drugs", a said David Nagib, assistant professor at The Ohio. State University.
"The story begins with carbonyls, compounds that are one of the most common elements in creating potential new drugs," Nagib said.
Unlike conventional carbonyl chemistry, taught in introductory textbooks, when carbonyls are converted to a "radical" form, they become much more reactive.
These radicals, containing an unpaired electron desperately seeking its partner, allow researchers to form new bonds to create complex, drug-like products.
Up to now, the formation of cetyl radicals has required strong and hard substances called reducing agents, such as sodium or samarium, to act as catalysts.
These reducers can be toxic, expensive and incompatible with the creation of drugs, said Nagib.
In this study, researchers found a way to use manganese as a catalyst that can be activated with a simple LED light.
"Manganese is very inexpensive and abundant, which makes it an excellent catalyst, it also allows us to access the radicals through a complementary atom transfer mechanism, rather than through the classical transfer mechanism." Electrons, "he said.
Manganese is not only cheaper and more abundant, but it is actually more selective in creating products with defined geometries, so that they can integrate with drug targets, revealed the ## 147 ## 39; study.
In addition, the process consumes less atmosphere by recycling the iodine atom used to make the radicals by including it in the most functional products.
This new method of generating cetyl radicals allows researchers to create more versatile and complex structures that could be useful for generating new drugs, said Nagib.
(This story has not been changed by Business Standard staff and is generated automatically from a syndicated feed.)
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