An offense already underway in the Buffalo Bills had to face another major change on Sunday.

Le Mans attacking midfielder McCoy was out for the remainder of the game against the Colts of Indianapolis after a head injury.

McCoy went to the locker room after a first quarter run.

The Bills were already without quarterback Josh Allen, who had been sidelined because of an elbow injury. The recently signed veteran, Derek Anderson, has taken his place.

McCoy, 30, had been the subject of commercial speculation before the 30 October deadline.

"Just to talk a little about this LeSean stuff, LeSean is one of our best players," said Bills coach Sean McDermott in October. "We get calls all the time, incoming calls are all the time. Brandon and I talk a lot and I will not go into detail. "

Follow Michael Middlehurst-Schwartz on Twitter @MikeMSchwartz.

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