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A second individual was diagnosed with a monkeypox in England, health officials said.
The patient, who had traveled to Nigeria, where he is thought to have contracted the infection, presented symptoms at Blackpool Victoria Hospital, said Public Health England (PHE).
This is the second case of rare viral infection recorded in the UK after a resident of Nigeria residing at a naval base in Cornwall was diagnosed last week.
However, there is "no connection between the UK" between the two patients, said PHE.
Monkeypox does not spread easily between people and most people contracting the infection will recover within a few weeks, although some serious illness may occur in some people.
Dr. Nick Phin, deputy director of the National Service for Infection Control at PSE, said it was "very unusual" to see two cases in a short period of time.
"We know that in September 2017, Nigeria experienced a significant prolonged outbreak of monkeypox and since then sporadic cases have continued to be reported," he said.
"It is likely that monkeypox continues to circulate in Nigeria and could therefore affect travelers returning from this part of the world. However, it is very unusual to see two cases in a relatively short space of time.
"We are working hard to reach people, including health workers, who could have contacted the person to provide information and health advice."
The second individual was transferred to Royal Liverpool University Hospital after being tested positive for infection.
Dr. Mike Beadsworth, Clinical Director of the Hospital's Tropical and Infectious Diseases Unit, said: "The patient is cared for by our specialized infectious and tropical diseases unit, by a highly qualified staff and experienced in various infectious diseases. .
"All necessary precautions are taken by specialized personnel and there is currently no risk for staff, patients or visitors."
The first person still receives care at the Royal Free Hospital in London.
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