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<p class = "canvas-atom canvas-text Mb (1.0em) Mb (0) – sm Mt (0.8em) – sm" type = "text" content = "Professor Ruth Itzhaki, who spent more than 25 years in Manchester University investigating a potential link between the twoAccording to studies conducted in Taiwan, the risk of dementia was much greater among people infected with the herpes simplex virus (HSV). "data-reactid =" 32 "> Professor Ruth Itzhaki, who spent more than 25 years at the University of Manchester investigating a potential link between the two, said studies conducted in Taiwan suggest that the risk of dementia was much greater in people infected with the herpes simplex virus (HSV).
There are two types of herpes simplex virus (HSV): HSV1, also called oral herpes, which causes cold sores and blisters around the mouth and on the face; and HSV2, which is generally responsible for outbreaks of genital herpes.
Professor Itzhaki said, "The most striking results include evidence that the risk of senile dementia is much greater in people infected with HSV and that antiviral treatment with herpes virus causes a dramatic decrease number of subjects severely affected by HSV1 dementia.
"HSV1 could account for 50% or more of Alzheimer's disease cases."
Professor Itzhaki used Taiwan for research, as 99.9% of the population is registered in a national health insurance research database, which is currently being researched for information on infections and infections. microbial diseases.
In 2017/18, three studies were published describing Taiwanese data on the development of senile dementia – the leading cause of which is Alzheimer's disease – and on the treatment of patients with obvious signs of infection by HSV or varicella-zoster virus (VZV – chickenpox virus). ).
<p class = "canvas-atom canvas-text Mb (1.0em) Mb (0) – sm Mt (0.8em) – sm" type = "text" content = "MORE: A man on the nudist beach survives the attack of a shark by hitting him in the head
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But Professor Itzhaki said: "It should be emphasized that the results of these Taiwanese studies only apply to serious HSV1 (or VZV) infections, which are rare.
"Ideally, we would study dementia rates in people with mild HSV1 infection, including cold sores. [cold sores] mild genital herpes, but they are much less likely to be documented. "
Cause and Effect – The Alzheimer Society stated that the research did not show a cause-and-effect relationship between herpes and dementia (Photo: Getty)
Professor Itzhaki has already shown that cold sores are more common in APOE-ß4 carriers, a variant of the gene that increases the risk of Alzheimer's disease.
"Our theory is that, in APOE-4 carriers, reactivation is more common or more damaging in brain cells infected with HSV1, which leads to the accumulation of damage that leads to development. of Alzheimer's disease, "added Professor Itzhaki.
"Viral DNA is very specifically found in plaques of post-mortem brain tissue in people with Alzheimer's.
"The major plaque and entanglement proteins also accumulate in HSV1-infected cell cultures – and antiviral drugs can prevent this."
The Alzheimer Society said the paper highlighted existing studies suggesting that people with the herpes virus were more likely to develop dementia, but because of the nature of the research, there is no evidence cause and effect relationship between herpes and dementia.
Dr. James Pickett, head of research for the association, said, "Herpes is a hot topic in dementia research because the infection appears to be more common in the brain of the people with Alzheimer's disease only in that of the brain in good health – but we still do not know enough about the relationship between the two.
"We think people should not worry about the link between herpes and dementia, although it makes sense to recommend treatment for the treatment of chronic cold sores.
"Dementia is not contagious and should not be considered an infectious disease.
"More research is needed to determine if antiviral drugs can reduce the risk of dementia. A person in the United Kingdom contracts dementia every three minutes and our scientists at the British Dementia Research Institute try to understand why and find a way to fight it. "
The research is published in Frontiers in Aging Neuroscience.
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