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A recent study conducted by researchers from the Tufts University School of Medicine conducted the first comprehensive comparison of the expression and regulation of gonococcal genes in men and in men. women. Neisseria Gonorrhoeae infected women, thus identifying gender-specific signatures in infection and in antibiotic resistance genes.
However, in the past decade, N. gonorrhea strains resistant to gonorrhea antimicrobials
In 2013, N. Gonorrhoeae was reported as a threat to public health. The World Health Organization estimates that 78 million people worldwide are infected with gonorrhea each year. Men with infections tend to have obvious symptoms while women are often asymptomatic or have mild symptoms. In men as in women, the infection usually disappears with antibiotic treatment.
"We relied on our earlier work on gene expression during infection in women to include both sexes in this analysis. "We discovered that when bacteria infect the male, it's a different gene expression profile than when they infect the female.When we consider how much the two environments are fundamentally different, it has to meaning, "she added
. Until now, the infection has been mainly studied in tissue culture, human models males and mice. These studies provided key insights into the interactions between bacteria and the host because according to Genco "they have important limitations, namely the lack of human response in humans."
"Study active infection in men and women"
To understand the disease in both sexes, the team of researchers examined the manifestation of the disease in a cohort of subjects attending a clinic that deals with sexually transmitted infections in a country where
Samples were taken from men who visited the clinic for gonorrhea treatment and from female partners who came to seek treatment after confirmation from diagnosis of their partner.
Researchers used sequencing RNA to identify host and bacterial genes expressed during a mucosal infection.
confirmed that nine percent Gonococcal genes exhibited increased expression exclusively in men and included genes involved in host immune cell interactions. Genome-wide DNA sequencing, men and women exhibited similar genotypes resistant to antibiotics, but researchers observed an expression of these genes four times more resistant to antibiotics. in men
The researchers finally noted that the limits include the small sample size and the potential variance in the stages of infection in males compared to females. A larger scale study using additional genetic analyzes is currently underway. The study appears in the mSphere log.
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