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A sticky protein found on the outside of cells could be the cause of breast cancer growth.
According to a new study, the protein called fibronectin is responsible for estrogenic activity in breast cancer cells. The study titled "Fibronectin rescues the estrogen receptor from lysosomal degradation in breast cancer cells," was conducted by Rocío Sampayo
The estrogen hormone plays a vital role in the development of healthy cells and, in many cases, cancerous. cells. Estrogen attaches to cellular estrogen receptors, which lead to cell growth and survival. However, the excess of estrogen receptor activity could lead to a very rapid cell proliferation, which could lead to tumor growth.
About 75% of breast cancers are considered positive for estrogen because cancers are multiplying. When cancer cells begin to invade the surrounding tissue, they encounter the sticky fibronectin protein
"In the normal mammary gland, epithelial cells are not in contact with fibronectin," said Sampayo
. Therapeutic agents that interfere with the influence of fibronectin on the estrogen receptor could be a means of treating drug-resistant breast cancers.
The study appears in the Journal of Cell Biology.
Another study by NIPER scientists found that Nimbolide, a chemical compound derived from the leaves and flowers of Neem, could be an effective cure for breast cancer.
The agency addresses various agencies such as biotechnology departments, AYUSH, so that they can secure funding for research and conduct clinical trials, said scientist Chandraiah Godugu.
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