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A vaccine used to treat tuberculosis (TB) may be effective in reducing hyperglycemia in people with type 1 diabetes, according to a new study from the Massachusetts General Hospital Immunobiology Laboratory, USA.
Type 1 diabetes is a chronic disease in which the pancreas produces little or no insulin. The results show that, three years after receiving two administrations of Bacillus Calmette-Guérin (BCG) vaccine four weeks apart, people with long-standing type 1 diabetes showed improved overall levels of sugar.
"This is a clinical validation of the potential to stably lower blood glucose levels to near normal levels with a safe vaccine, even in patients with a disease-related condition." long time, "said Denise Faustman, director of the Massachusetts Immunobiology Laboratory.
The study, published in the journal npj Vaccine, also reported that the effects of BCG vaccine on glycemic control appear to be dependent on a new metabolic mechanism that increases glucose cell consumption. The team analyzed data from 282 human participants – 52 with type 1 diabetes who participated in BCG clinical trials and 230 who provided blood samples for mechanistic studies.
The results showed that HbA1c levels of those who received BCG had decreased by more than 10% in the three years following treatment and by more than 18% in four years.
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