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What role does inflammation play in Alzheimer's disease?
Scientists have looked into this issue. And a new study from the Boston University School of Medicine could provide another piece of the puzzle.
The researchers said that possession of the ApoE4 gene had already been the major genetic risk factor for Alzheimer's disease, but it was unclear why some people with the gene did not contract the disease.
Researchers, using data from the Framingham Heart Study, found that the risk of Alzheimer's disease was significantly increased in people with the gene who also had chronic inflammation.
The results were published in the journal JAMA Network Open.
The researchers suggested that treating the chronic inflammation that many older people suffer could possibly prevent the destructive disease of the mind.
"It's possible that chronic inflammation … interacts with genetic vulnerability to increase the risk of AD," said the study.
"Since many seniors suffer from chronic inflammation of low grade after suffering from common diseases such as cardiovascular disease, diabetes, pneumonia and urinary tract infections, or after surgery, rigorous treatment chronic systemic inflammation of ApoE4 carriers could be effective in preventing Alzheimer's dementia "Wendy Qiu, a professor at the faculty of medicine who was the corresponding author of the study, said in a statement.
The researchers used data from the Framingham Heart Study, which includes more than 3,000 human subjects. They examined people with the ApoE4 gene and measured their C-reactive protein level, indicating the extent of inflammation in the body.
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