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New research has linked adolescents with pancreatic cancer later in life. The study's findings also suggest that cancer can increase the risk of cancer. The findings are published early online CANCER, a peer-reviewed journal of the American Cancer Society.
Pancreatic cancer is the sixth most common cause of cancer-related deaths in the world, and studies have linked adult obesity with an increased risk for its occurrence. To uncover any potential associations with adolescent weight, Zohar Levi, MD, of Rabin Medical Center and Tel Aviv University, and his colleagues analyzed 1,087,358 Israeli Jewish men and 707,212 Jewish women who underwent a compulsory physical examination between the ages of 16 and 19 years from 1967 to 2002. Pancreatic cancer incidence through 2012 was identified by the Israeli National Cancer Registry.
Over 55,000 new cases of pancreatic cancer cases were identified, including 423 cancers among men and 128 cancers among women. Compared with normal weight (5th to
Among men, high-normal BMI (? 75th to
"The overall population attributable fraction of pancreatic cancer due to adolescent overweight and obesity was 11 percent among this Israeli Jewish population," said Dr. Levi.
An accompanying editorial by Chanan Meydan, MD, of the Mayanei Hayeshua Medical Center in Israel, highlights systemic inflammation caused by obesity as a potential driver behind the development of pancreatic cancer.
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