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IANS
Washington, Sept 11 (IANS) The US National Cancer Institute has awarded the Outstanding Investigator Award to Professor Arul Chinnaiyan of the University of Michigan and $ 6.5 million over seven years to identify cancer biomarkers targeted therapies.
"The field of precision oncology continues to evolve with the overarching goal of providing cancer patients with improved diagnostic and prognostic capabilities and better treatments," Chinnaiyan said in a statement. communiqué, Monday evening.
"This grant will help us identify new biomarkers and understand their biological roles in cancer progression," he added.
A pioneer of precision oncology, Chinnaiyan in 2010, launched the Michigan Oncology Sequencing Program (Mi-ONCOSEQ).
Mi-ONCOSEQ is a research protocol for DNA and RNA sequencing of metastatic cancers and normal tissues to identify alterations that may promote treatment.
The program includes a table of precision tumors in which experts discuss each case.
The Chinnaiyan laboratory also analyzed the global landscape of a part of the genome that had not yet been well explored – long non-coding RNAs (lARNRNA).
Earlier, considered as dark matter, new evidence suggests that lncRNAs may play a role in cancer and that their better understanding could lead to potential new targets for improving the diagnosis, prognosis or treatment of cancer.
Chinnaiyan's laboratory has also identified and explored several lncRNs that could be promising targets for future therapy.
"We want to further characterize the dark matter of the genome.Some of these lncRN will certainly be very useful as biomarkers of cancer and we think that a subset is important in biological processes," noted Chinnaiyan.
"We hope patients will have a molecular model of their tumor to guide treatment choices."
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Updated: September 12, 2018
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