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DALLAS, Oct. 1, 2018 – Fluctuations in weight, blood pressure, cholesterol and / or blood glucose levels in healthy people could be associated with a higher risk of heart attack, stroke and death. readings, according to a new research in the journal of the American Heart Association circulation.
This study is the first to suggest that a high variability of these risk factors has a negative impact on relatively healthy people. The study is also the first to indicate that having multiple measurements with high variability increases the risk.
Compared with those who had stable measures during an average follow-up period of 5.5 years, the individuals with the greatest variability (in the top 25%) on all measures were:
- 127 percent more likely to die;
- 43% more likely to have a heart attack;
- 41 percent more likely to have a stroke.
Using data from the Korean health insurance system, the researchers looked at data from 6,748,773 people who had never had a heart attack and without diabetes, high blood pressure or high cholesterol at the beginning of the study . All participants underwent at least three health exams between 2005 and 2012 (it is recommended in the system every two years). Records of documented examinations of body weight, fasting blood glucose, systolic blood pressure (maximum number) and total cholesterol.
Since high variability may result from positive or negative changes, researchers examined separately the effect of variability among participants that had been improved or worsened by more than 5% at each measurement. In the enhanced and aggravated groups, high variability was associated with a much higher risk of death.
"Care providers need to pay attention to the variability in blood pressure, cholesterol, glucose, and body weight measurements, and trying to stabilize these measures can be an important step towards improving one's health," he says. said Seung-Hwan Lee. , MD, Ph.D., lead author of the study and professor of endocrinology at the Faculty of Medicine of the Catholic University of Korea in Seoul, South Korea.
The study was observational, which means that she can not prove a cause-and-effect relationship between high variability and risk of heart attack, stroke or death, whatever In the cause. The study also did not explore the reasons for fluctuations in risk factor measures by participants.
"It is not certain that these Korean results would apply in the US However, several previous studies on variability have been performed in other populations, suggesting that "It will probably be a common phenomenon," Lee said.
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The co-authors are Mee Kyoung Kim, M.D., Ph.D .; Kyungdo Han, Ph.D .; Yong-Moon Park, M.D., Ph.D .; Hyuk-Sang Kwon, M.D., Ph.D .; Gunseog Kang, Ph.D .; and Kun-Ho Yoon, M.D., Ph.D. The revelations of the authors are on the manuscript.
The National Research Foundation of Korea funded the study.
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The statements and conclusions of the authors of the study published in the scientific journals of the American Heart Association are solely those of the authors of the study and do not necessarily reflect the policy or position of the 39; association. The Association makes no representations or warranties as to their accuracy or reliability. The association receives funds mainly from individuals. Foundations and companies (including pharmaceutical companies, device manufacturers and other companies) also donate and fund specific programs and events. The Association has strict policies to prevent these relationships from influencing scientific content. Revenues of pharmaceutical and device companies and health insurance providers are available at https: /
About the American Heart Association
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