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A modified form of botulinum toxin, popularly known as Botox, provides relief from chronic pain without adverse effects, according to a study published today in the journal Science Translational Medicine ]. ] Researchers at University College London ( UCL ) deconstructed the botulinum molecule and reassembled it with an opioid type, which resulted in a compound that silences the pain signals "Injected into the spine, it relieves chronic pain, like that caused by nerve damage, and avoids the unwanted effects of tolerance and dependence often associated with the repeated use of opioid drugs, "says lead author, Steve Hunt UCL.
According to the researcher, this new mix does not affect muscles like botulinum toxin used to treat reduce wrinkles, but block the nerve pain up to four months without affecting the normal responses to pain.
Hunt felt that this product "could revolutionize the way chronic pain is treated" if it is transferred to the cl unjust because it would eliminate the need for a daily intake of opioids.
Chronic pain of "moderate to severe" intensity is prevalent and affects 7.8 million people in the UK and 19% of European adults.
Opioids such as morphine and fentanyl are considered the usual mechanism of pain relief, but there is little evidence that their use is effective in the long-term in the treatment of chronic pain.
Over time, the body develops a tolerance to the repeated use of these drugs.
Another point against the use of opiates is that they can activate the areas of the brain that cause addiction. More than 2 million people in the United States, for example, have an opioid consumption disorder.
In an attempt to solve this problem, the Hunt-led team developed a molecular system for the creation of long-acting painkillers.
Over a five-year period, they used 200 mice to simulate the early stages of neuropathic and inflammatory pain in humans and were treated with a single injection of the mixture, another modification of the botulinum molecule .
The behavior of the mice was monitored to track their pain response and localizations and binding properties of botulinum compounds were studied.
"We were impressed to see that a small injection of the mixture developed was enough to stop the chronic pain caused by inflammation for at least a month," said Maria Maiarù, another of the researchers of the UCL team.
2018-07-18
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