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Researchers at University College London deconstructed the botulinum molecule and reassembled it with an opioid type, which resulted in a compound that silenced the pain signals in the spinal cord of the mice.
"Injected into the spine, it relieves chronic pain, such as that caused by nerve damage, and avoids the detrimental effects of tolerance and dependence often associated with the repeated use of opioid drugs", says one of the According to the researcher, this new mix does not affect muscles like botulinum toxin used to reduce wrinkles, but it blocks nerve pain up to four months without affecting normal responses to pain. .
Hunt felt that this product "could revolutionize the way chronic pain is treated" when it is transferred to the clinic, as this would eliminate the need for a daily intake of opioids.
Tests with mice
Chronic pain of "moderate to severe" intensity is widespread and affects 19% of European adults, studies show. Opioids such as morphine and fentanyl are the usual methods of pain relief, but there is little evidence that their use is effective in the long-term in the treatment of chronic pain.
This is because over time the body develops a tolerance for the repeated use of these drugs.
Another point against the use of opiates is that they can activate the areas of the brain that are addictive. More than 2 million people in the United States, for example, have a disorder of opioid use.
In an attempt to solve this problem, the Hunt-led team developed a molecular system that allows the creation of long-lasting analgesics without the side effects of opioids.
Over a five-year period, they used 200 mice to simulate the early stages of human neuropathic and inflammatory pain and were treated with a single injection of the mixture, another modification of the botulinum molecule or morphine. behavior of mice to track their response to pain and the locations and binding properties of botulinum compounds were studied.
"We were impressed to see that a small injection of the mixture developed was enough to stop the chronic pain caused by inflammation for at least a month," said Maria Maiarù, another researcher from l & # 39; team.
treatment with botulinum toxin, the famous botox, the patient told me that years ago she would never have considered botox, seeing that she has saw how many famous people have ended up deformed or with the face of a comic. Botulinum toxin has a very bad reputation, but among health professionals, the opposite occurs because it is a very safe treatment that gives great satisfaction to the doctors. The truth is that botulinum toxin is used in all medical disciplines, for pathologies such as migraines, hyperhidrosis, muscle spasms, strabismus, and many others with very good results and a excellent security profile. # doctora1minuto #anamolina # dermatología #beauty #toxinabotulinica #rellenos Foto @evaeme
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