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Mexico – Scientists from the National School of Medicine and Homeopathy (ENMH) have verified the effectiveness of the Belladona plant against prostate cancer, said National Polytechnic Institute (IPN) of Mexico in a statement. According to the researchers, after five years of studies, the molecular tests of extracts, fractions and pure compounds of the Kalanchoe flammea plant have shown the presence of secondary metabolites called glycosides and cardiotonic terpenes, for no reason. name only a few
. Dr. Cynthia Ordaz Pichardo, the scientists conducted preclinical studies of the extract (in vitro and in vivo) of the plant Kalanchoe flammea.
The specialists carried out cytotoxicity tests on the tumor cells and the healthy cells to exclude any damage to the latter. and "Belladonna" was safe for healthy cells.
With these findings, a patent was issued for the use of plant components in this type of dysplasia in the name of IPN.
The researchers explained that they evaluated extracts, fractions and pure compounds in animal models. First, in a mouse xenotransplantation model to demonstrate antitumor activity.
Next, they evaluated the toxicity of Kalanchoe flammea in rats and rabbits, which were subjected to laboratory studies and histopathological analyzes.
The research protocol also included pharmacodynamic and pharmacokinetic interactions, so that tests of the Belladona extract in combination with the drug Docetaxel were repeated again.
Dr. Ordaz Pichardo explained that there was a synergy between the two treatments that helped kill the tumor cells, decreasing the concentrations and doses of the extract and the drug without harming the healthy cells.
The specialist has indicated that the mixture of Belladona extract with Docetaxel reduces the side effects of the disease, that quality and life expectancy improve in the xenotransplant model It has expressed its enthusiasm to conclude shortly the tests on patients to put the drug on the market, with scientific support, and to make the transfer of technology that allows its commercialization and internationalization of the patent.
who is about to begin the clinical phase in patients to obtain a herbal drug that is marketed in a controlled manner.
Belladonna is a medicinal plant known for its analgesic properties, used in treatments against asthma, menstrual pain or ulcers. stomach
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