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The discovery shows the way to a new class of antidepressants that could be more free of side effects and faster action.
Reference picture, Pixabay.
A team of researchers associated depression with low levels in the blood acetylcarnitine synthesized naturally in the body and also marketed as a nutritional supplement ] according to a study published Monday in the journal Pnas.
The discovery, which is based on extensive research with animals, opens the way to a new class of antidepressants that could be ] more free of side effects and more rapid action than those currently used, according to one of the lead authors, Natalie Rasgon . 1]
Depression, also called major depressive disorder or clinical depression, is the most common mood disorder in the United States and the world, affecting between 8 and 10% of the general population at a given moment. 19659007] Record Saved: Depression, Critical Illness and Misunderstood
"This is the main reason for absenteeism at work and one of the leading causes of suicide . Worse still, current pharmacological treatments are effective only for about 50 percent of the people who are prescribed "said Rasgon.
In experiments with rodents, acetylcarnitine deficiency a was associated with behavior similar to depression while oral or intravenous administration of this substance reversed the symptoms of animals and restored normal behavior.
See Also: Hypersomnia, a disorder that can be confused with depression
Animals responded to acetylcarnitine supplementation within a few days.On the contrary, current antidepressants took two to four weeks to appear both in the experiments with mice and between patients.
"Acetylcarnitine is a crucial mediator of fat metabolism and the production of Energy throughout the body and plays a special role in the brain, "says another author, Carla Nasca Rockefeller University of New York, United States
] See also: Ketamine rapidly suppresses suicidal tendencies in depressed patients
In a parallel analysis of the same team, Nasca and colleagues studied men and women aged 20 to 70 diagnosed with depression .
By comparing their blood samples with those of 45 matched demographically healthy individuals, it was found that levels of acetylcarnitine in patients' blood were substantially lower, "according to the authors .
A more detailed report showed that the lowest levels were among the participants whose symptoms were more severe whose medical records indicated that ] were resistant to previous treatments or at the beginning of the disease
Recommended: Depression, Drugs and Unemployment of Suicide Factors in Quindío
Levels of Acetylcarnitine ] Were Also Lower in Patients Reporting History abuse, neglect, poverty or exposure to violence during childhood
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