10-year-old child with rare disease linked to COVID-19 undergoes 4 amputations

A 10-year-old boy from Michigan has had four amputations of his hands and legs after a rare episode of severe inflammatory disease linked to the coronavirus.

Dae’Shun Jamison was diagnosed with Multisystem Inflammatory Syndrome in Children (MIS-C) and had her right leg amputated in early February at Helen DeVos Children’s Hospital, spokesperson for Mary Free Rehabilitation Hospital Bed, where the boy entered rehabilitation and recovery, confirmed to Fox News. The child was transferred to Helen DeVos Children’s Hospital on Monday for amputations of both hands and his left leg.

Brittney Autman, the mother of the child, detailed the story on a related GoFundMe page, writing on Tuesday: “Dae’Shun is very emotional about her amputations and it breaks my heart. Please keep the prayers coming.

Patients with this rare and severe inflammatory disease could experience limb loss due to a hyperinflammatory response affecting the body’s blood clotting ability, an expert explained.

According to Dr Rosemary Olivero, head of pediatric infectious diseases at the Helen DeVos Children’s Hospital, some patients with MIS-C suffer from severe heart dysfunction, affecting the way the body pumps blood to the rest of the body. Heart dysfunction, coupled with problems with blood clotting or bleeding, can lead to blockage of blood flow throughout the body, she said.

Autman said her son needed to have his hands amputated “due to lack of blood flow and damaged tissue in his hands,” also wrote last month: “Dae’Shun has [sic] has had a blood clot in the artery in his right hand for more than 2 weeks and the anticoagulants he is taking are [sic] It does not work…”

“Some patients with MIS-C have really extreme changes in their blood clotting factors. Some of them may actually clot too much in some parts of their body, and then too little in other parts of their body, ”Olivero said, later adding,“ Improper clotting is one of the many very consequences. serious effects of MIS-C. It doesn’t happen in all patients, but it can happen in some and can really lead to additional organ damage due to the mechanics of the blood flow.

As healthcare professionals have become more proficient in standardized care for MIS-C, the syndrome continues to be incredibly difficult due to the complex nature of the disease, Olivero said.

When the child learned of the amputations in January, Autman wrote, “He got it all. He understood that when he [would] waking up his leg will not be the same. Dae’Shun completely broke down in tears [sic] me in so many ways.

The boy had struggled with a severe course of the disease throughout the winter, with his mother detailing his treatment involving kidney dialysis, lung support and a feeding tube.

Olivero said the amputations resulting from the MIS-C are “a very unique and unfortunate consequence”.

MIS-C usually occurs several weeks after a previous infection with COVID-19 and can lead to organ damage due to a hyperinflammatory response.

“Your body excretes a ton of inflammatory chemicals that really spread the immune system, which can be very damaging to organs in the body,” explained Olivero, detailing MIS-C.

Treatments aim to relieve an intense inflammatory response involving a reaction to an infection. More specifically, the treatments involve IVIG (intravenous immunoglobulin treatment), or pools of antibodies with particularly potent anti-inflammatory characteristics, as well as steroids to calm the immune system. Children with persistent inflammatory problems, or those requiring intensive care, may receive more targeted anti-inflammatory drugs or immunomodulators.

If a child is infected with COVID-19, they usually tend to fare better, developing only mild or asymptomatic illness. This could make it difficult for parents to detect a case of MIS-C early. However, significant community transmission of COVID-19 will likely increase the prevalence of MIS-C, and parents should monitor children for signs such as fever, vomiting, abdominal pain, diarrhea, inflammation of the skin, eyes, hands. or feet, rash. or red lips or eyes, Olivero said. Some children have swollen hands or feet, while others have enlarged lymph nodes.

The expert recommended any parent concerned about MIS-C to immediately contact their doctor for an evaluation.

According to data from the Centers for Disease Control and Prevention (CDC), there were more than 2,000 cases of MIS-C reported nationwide as of February 1, disproportionately affecting minority populations.