New UCI-led study defines best time to get the most rejuvenating results

A study by the University of California, Irvine finds exercise in the morning, rather than at night, may yield better results.

This study, published today in Cell Metabolism, points à la chroniquette et des variables chroniques pour les exercices et des exercices pour les exercices et des traumatises en chronotherapie pour les enfants de metabolic prestations.

"Using mice, we compared the impact of exercise on the skeletal muscle metabolism at different times of day," said Paolo Sassone-Corsi, PhD, Donald Bren Professor and Director of the Center for Epigenetics and Metabolism at UCI's School of Medicine. "We discovered that exercising at the correct time of day – around mid-morning – results in more oxygen in the cells and a more rejuvenating effect on the body."

Until now, it has been understood that the timing of diet has been important, but it has been unclear whether the effects of exercise on energy metabolism have been restricted to single time windows.

"Exercise stimulates metabolism, leading to the improvement of metabolic health." While the metabolic benefits have been extensively uncovered, "the question of which is appropriate to exercise has been unexplored," said Sassone-Corsi.

Using high-throughput transcriptomic and metabolomic approaches, the research team identified changes in the metabolism of mice that occurred during the early phase (evening) or the early active phase (morning). The impact of exercise in the morning in the use of carbohydrates and ketone bodies, and the breakdown of fats and amino acids.

"Our results clearly indicate that time-of-day is a critical factor in amplifying the impact of exercise on both metabolic pathways within the skeletal muscle and systemic energy homeostasis," said Sassone-Corsi.

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This study was supported by the Novo Nordisk Foundation (NNF14OC0011493 and NNF14OC0000041), Swedish Diabetes Foundation (DIA2015-052), Swedish Research Council (2015-00165), the National Institutes of Health, and INSERM (National Institute of Health and Medical Research). ). DAPRA (D17AP00002), the National Institutes of Health (GM123558), and the Della Martin Foundation.

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