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(June 5, 2019 / JNS) Researchers at Tel Aviv University have discovered a new way to detect a protein associated with Parkinson's disease that could "significantly delay" the progression of the disease, for which there is currently no cure.
According to the researchers, they have developed a new method for tracking the early stages of the accumulation of alpha-synuclein protein, which slowly oxidizes cells in a part of the brain called the substantia nigra. Scientists said that by the time most patients were diagnosed with Parkinson's, 50-80% of the cells in the substantia nigra were already dead.
The study was conducted in collaboration with the University of Cambridge, which provided a mouse model of Parkinson's disease allowing scientists to study the different stages of alpha-synuclein accumulation.
Israeli scientists have also partnered with the Max Planck Institute in Göttingen and the Ludwig-Maximilians University of Munich to study the effects of a drug called anle138b on protein and have discovered a reversal of motor behaviors in treated mice.
The research was published on June 5 in the Acta Neuropathologica medical journal.
Professor Authors Uri Ashery, director of the Sagol School of Neuroscience at Tel Aviv University, and Dr. Dana Bar-On, also of the Sagol School of Neuroscience, said that research was promising because of the potential for detection and treatment of Parkinson's disease before symptoms. even develop and in a minimally invasive way.
Around the world, about 10 million people have Parkinson's disease.
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