Scientists suggest that the biological age of humans is reversed by the years of study



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Scientists could perhaps reverse the aging process, might suggest a new study.

According to the new study, volunteers who received a cocktail of drugs for a year lose on average 2.5 years of their biological age. Research has shown that the marks on their genomes that represent their "epigenetic clock" as well as their immune system have improved despite the passage of time.

The scientists involved in the study were shocked by the results.

"I was expecting a slowing down of the clock, but not a reversal," said researcher Steve Horvath of the University of California Los Angeles. Naturewho first reported the results. "It was a bit futuristic."

The scientists point out that the study was conducted with a very limited number of participants: only nine people took the cocktail of drugs and there was no control group. But if this is confirmed by other research, it could have huge impacts on health care, the treatment of diseases and the way people think about aging, they said.

In the study, participants received growth hormone and two antidiabetic drugs. They then observed the effect on the epigenetic clock of people, in order to understand the effect on their aging.

The epigenetic clock is measured by the epigenome in the body. As people get older, chemical changes or labels add to the DNA of people and these change throughout their lives. So, by looking at these labels, one can measure a person's biological age.

The researchers actually intended to look at how the growth hormone changes the thymus tissue, which contributes to the proper functioning of the immune system and is located in the chest. It normally contracts after puberty but they hope to see if we could push it to grow back by giving the growth hormone to the participants.

It is only a secondary consideration that the researchers then checked how the drugs were changing their epigenetic clock. The study was completed when the analysis began.

Professor Horvath then examined four different measures of the epigenetic clock to understand the different ages of each patient. And he found that each of them had reversed in a significant way – so significantly that he was optimistic about the results, despite the limited number of participants.

Scientists now hope to be able to test the same effects with more people, through a controlled study, and with different age groups, different ethnicities and women.

The changes were still visible in the blood of six participants who provided their blood long after the end of the study.

Some of the drugs used in the cocktail are already being researched in order to combat age-related diseases. But the discovery of the effect of these three drugs could have major consequences on how a variety of different drugs are tested, say the scientists.

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